Barcode-Tracked Sample Transfer Device for 96-Well Plates
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Solution Overview
Problem
Current methods for collecting and processing biological samples, such as swabs, are manual and prone to errors in sample placement and documentation, especially when transferring samples into 96-well formats for analysis, and existing devices may require invasive collection methods or incompatible stabilization solutions.
Innovation Solution
A device system comprising a detachable sample collection assembly, a collection/extraction basket, a place holder, and a hinged holder, which allows for barcode identification and automatic tracking of sample positions, enabling direct transfer of biological samples into a 96-well microtiter plate without manual handling and compatible with liquid handling instruments or magnetic processors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If manual transfer of swab samples into 96-well plates is performed, then sample processing can be completed, but sample switching errors occur and documentation accuracy decreases
Solution Approach 1:
The patent replaces manual mechanical transfer operations with an automated system that uses magnetic processors and liquid handlers to transfer samples from swabs to 96-well plates. The automated system reads barcodes to identify samples and automatically places them in the correct wells, eliminating human error while maintaining high throughput processing capability.
Solution Approach 2:
The system enables self-service through automated sample identification and tracking. Barcode readers automatically capture sample information, and the system autonomously tracks sample locations throughout the processing workflow without requiring manual documentation, ensuring both accuracy and efficiency.
2Reliability
If existing collection devices transfer biological material to stabilization solution, then sample preservation is achieved, but compatibility with laboratory chemistry for DNA, RNA or protein extraction is compromised
Solution Approach 1:
The patent changes the chemical parameters of the stabilization solution to achieve compatibility with downstream DNA, RNA, and protein extraction protocols. The modified stabilization solution maintains sample preservation capabilities while eliminating chemical incompatibilities that prevented direct use with laboratory extraction chemistry.
Solution Approach 2:
The stabilization solution is designed to serve multiple functions: preserving biological samples during transport and simultaneously being compatible with various laboratory extraction protocols for DNA, RNA, and proteins, eliminating the need for additional sample transfer steps.
3Productivity
If automated liquid handlers and magnetic processors are used for sample processing, then processing efficiency increases, but the complexity of the system increases
Solution Approach 1:
The patent segments the sample processing system into distinct functional modules: sample collection with barcoded identification, automated transfer using magnetic processors, and liquid handling operations. This modular segmentation allows each component to be optimized independently while working together to achieve high processing efficiency.
Data Source
AI summary
A device system, and method of use thereof, for collecting, transporting, and processing a biological sample is provided.