Barium Silicate Cement Radiopacity Biocompatibility

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Solution Overview

Problem

There is a lack of studies on the biological properties of Barium silicates, which are essential for developing effective biocompatible and bioactive cements for medical and dental applications.

Innovation Solution

A barium cement formulation that includes barium silicate compounds, such as di-barium silicate, tri-barium silicate, mono-barium aluminate, di-barium aluminate, and tri-barium aluminate, which are capable of hydrating to form a hydrogel, is developed. This cement is designed to be biocompatible, bioactive, and radiopaque, suitable for dental and medical procedures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Illumination intensity

If barium silicate compounds are used as the primary cement material, then radiopacity and bioactivity are improved, but the lack of biological property studies creates uncertainty about biocompatibility

Engineering Contradiction:

ImproveradiopacityVSAvoidbiocompatibility assurance

Core Design Contradiction:

Illumination intensityVSReliability

Solution Approach 1:

The patent modifies the chemical composition parameters by incorporating specific barium silicate compounds (Ba2SiO4, Ba3SiO5, BaSiO3) in controlled proportions alongside calcium silicate compounds. This parameter change achieves radiopacity through barium content while managing biocompatibility through the established bioactivity of calcium silicate components, effectively resolving the contradiction between improved radiopacity and uncertain biocompatibility

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite cement material combining barium silicate compounds with calcium silicate compounds. This composite approach leverages the radiopacity of barium silicate while utilizing the well-documented biocompatibility and bioactivity of calcium silicate, thus achieving both improved radiographic visibility and reliable biocompatibility without requiring extensive new biological studies

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If the cement is designed to hydrate and harden in physiological environment, then setting capability in aqueous environment is improved, but premature hydration during storage must be prevented

Engineering Contradiction:

Improvesetting in aqueous environmentVSAvoidstorage stability

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

The patent extracts water from the cement composition by using a water-free liquid carrier (such as organic acids or esters) instead of water. This extraction prevents premature hydration during storage while maintaining the ability to set in aqueous physiological environments, as the water is provided by the biological fluid itself rather than being present in the mixed cement

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention introduces a water-free liquid carrier as an intermediary substance that replaces water in the cement mixture. This intermediary allows the cement to remain stable during storage without hydrating, yet still enables hydration and setting when exposed to physiological fluids in the body, effectively mediating between storage stability and setting capability

Inventive Principle:

Principle #24Intermediary (Mediator)

3Illumination intensity

If barium silicate compounds are used as fillers in polymer compositions, then radiopacity is improved, but polymerization shrinkage and disrupting stress remain significant issues

Engineering Contradiction:

ImproveradiopacityVSAvoidpolymerization stress

Core Design Contradiction:

Illumination intensityVSStrength

Solution Approach 1:

The patent replaces the polymer matrix system with a cement-based hydraulic binding system. Instead of relying on polymerization reactions that cause shrinkage and stress, the invention uses barium silicate and calcium silicate compounds that set through hydration reactions with physiological fluids. This substitution eliminates polymerization shrinkage and associated disrupting stresses while maintaining radiopacity through barium content

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The barium cement demonstrates high biocompatibility and bioactivity, forming a hydroxyapatite layer that encourages new bone growth, and exhibits high radiopacity, making it suitable for various medical and dental applications.

Implementation Method 1

The barium silicate compound hydrates with water to produce a barium hydrogel compound, as a structural component, and barium hydroxide

Methodology Applied

Scientific EffectHydration: Mineral Hydration

Implementation Method 2

forming a hydroxyapatite layer that encourages new bone growth

Methodology Applied

Scientific EffectHydroxyapatite formation: Crystallisation

Data Source

PatentUS20250032367A1Barium silicate cement for dental and medical applications, and methods of use

Publication Date: 2025.01.30 YANG QUANZU

AI summary

A cement is provided for use in medical and dental procedures. The cement includes a barium silicate compound, and is formulated to be biocompatible and bioactive. The barium silicate compound is in the form of a powder, and includes one or more of a di-barium silicate, a tri-barium silicate, a mono-barium aluminate, a di-barium aluminate, and a tri-barium aluminate. The cement can optionally be provided as a premixed paste in which the cement powder is mixed with a nonaqueous liquid.