Baroreceptor Activation Structure for Phase-Synced Blood Pressure Reduction
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Solution Overview
Problem
Existing treatments for conditions like hypertension, heart failure, and coronary heart disease related to baroreceptor-mediated physiological processes are inadequate or ineffective in many patients.
Innovation Solution
A method and device for stimulating baroreceptors in arteries by applying varying forces during different phases of the cardiac cycle using a baroreceptor activation device, which includes longitudinal struts and connecting members to stretch the receptors, and optionally altering tissue stiffness or delivering substances/energy to facilitate blood pressure reduction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing drugs and devices are used to treat hypertension and cardiovascular conditions, then treatment coverage is provided, but effectiveness is inadequate for many patients
Solution Approach 1:
The device applies dynamic, phase-synchronized forcing to the artery wall that adapts to the cardiac cycle. The baroreceptor activation device delivers different amounts of force during different phases (systole vs diastole) to optimize baroreceptor stimulation effectiveness, making the treatment responsive to physiological variations rather than static
Solution Approach 2:
The device concentrates mechanical forcing at specific locations on the artery wall where baroreceptors are present, rather than applying uniform treatment throughout. The connecting members apply force at spaced-apart locations to selectively stimulate baroreceptor regions, creating localized physiological effects
2Reliability
If a baroreceptor activation device applies force to stretch baroreceptors during blood pressure variations, then blood pressure control is improved, but device complexity increases
Solution Approach 1:
The device utilizes the natural periodicity of the cardiac cycle to deliver mechanical forcing at appropriate phases. By synchronizing the application of force with systolic and diastolic phases, the device achieves effective baroreceptor stimulation without requiring complex active control mechanisms, leveraging the body's own rhythmic physiology
Solution Approach 2:
The device structure is divided into multiple connecting members that apply force at spaced-apart locations along the artery. This segmentation allows the complex task of blood pressure control to be distributed across multiple simpler mechanical elements rather than requiring a single complex mechanism
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method and device effectively stimulate baroreceptors to reduce systemic blood pressure, providing a novel approach to treat hypertension and related conditions.
Implementation Method 1
applying a first amount of force to a region of a wall of the artery with a baroreceptor activation device implanted in the artery to stretch a baroreceptor in the wall during a first local blood pressure of a cardiac cycle within the artery; and applying a second amount of force to the region of the wall of the artery with the baroreceptor activation device during a second local blood pressure of the cardiac cycle within the artery
Implementation Method 2
optionally altering tissue stiffness to modulate blood pressure
Data Source
AI summary
Devices and methods described herein may, among other uses, favorably cause the activation and/or deactivation of vascular baroreceptors in order to achieve a desired impact on a physiological condition, such as baroreflex-regulated conditions, hypertension, hypotension, nervous system disorders, metabolic disorders, cardiovascular disease, heart failure, cardiac arrhythmia, renal disease, respiratory disease, diabetes, and insulin resistance. The devices and methods may be used in concert with each other and/or other treatments, medications, interventions, or behavioral regimens. They may also be used in concert with devices and methods that perform or assist with assessing or measuring a mammal's blood pressure, assessing, measuring, or predicting the impact of the described methods and devices on the patient's condition (including blood pressure), and/or protecting the surrounding anatomy from adverse effects.