Baroreceptor Testing for Hypertension Implant Selection
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Solution Overview
Problem
Current methods for treating hypertension through baroreceptor modulation are not effective for all patients, as some subjects may not respond or respond only partially to implantable devices, necessitating a need for improved screening and therapy selection methods.
Innovation Solution
The development of systems and methods that involve providing mechanical stimuli to blood vessels to alter their curvature and strain, allowing for the selection of an optimal implant based on physiological responses, such as baroreflex responses, to enhance therapeutic outcomes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If implantable baroreceptor modulation devices are used to treat hypertension, then blood pressure regulation is improved, but treatment efficacy varies significantly across different patients with some showing no response or only partial response
Solution Approach 1:
The patent applies preliminary action by conducting baroreceptor testing before implantation to identify patients who will respond to baroreceptor modulation therapy. The testing system applies mechanical stimuli to the carotid sinus and measures baroreflex responses in advance, allowing clinicians to screen patients and select only those likely to benefit from the implantable device, thereby improving overall treatment efficacy and reducing unnecessary procedures.
2Reliability
If mechanical stimuli are applied to blood vessels to modulate baroreceptor activity, then baroreflex response is enhanced, but the complexity of screening and therapy selection increases
Solution Approach 1:
The patent applies feedback by measuring baroreflex responses during testing and using this information to guide implantation decisions. The system provides real-time feedback on patient responsiveness to mechanical stimuli, allowing clinicians to assess baroreceptor function and determine optimal treatment strategies based on actual physiological responses rather than relying solely on clinical diagnosis.
Solution Approach 2:
The patent applies self-service by using the patient's own physiological responses to baroreceptor stimulation as the basis for treatment selection. The testing system leverages the body's natural baroreflex mechanism to generate measurable responses that automatically indicate treatment suitability, eliminating the need for complex external assessment protocols.
3Measurement precision
If baroreceptor testing is performed before implantation, then patient selection accuracy is improved, but the time and resources required for screening increase
Solution Approach 1:
The patent applies mechanics substitution by replacing complex clinical assessment procedures with a simplified mechanical stimulation and measurement system. The testing device uses controlled mechanical stimuli applied to the carotid sinus and automated measurement of physiological responses, substituting for lengthy manual clinical evaluations and providing objective, quantifiable data for patient selection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for personalized therapy by identifying suitable implants that effectively modify baroreflex responses, improving blood pressure regulation and treatment efficacy for hypertensive patients.
Implementation Method 1
providing a mechanical stimulus to a blood vessel, wherein the mechanical stimulus generates an increased radius of curvature at a first region of the blood vessel and a decreased radius of curvature at a second region of the blood vessel
Data Source
AI summary
Systems and methods for screening a subject for a therapy are described. A mechanical stimulation device positioned near at target location of a blood vessel to provide a mechanical stimulus to the blood vessel. The mechanical stimulus increases strain in one or more regions of the blood vessel, such as by modifying the cross-sectional geometry and/or area of the blood vessel to have different regions of different curvature A baroreflex or related physiological response in response to the mechanical stimulation is detected. In response to the detected response, it is determined whether the subject is appropriate for the therapy and/or which of a plurality of implants with different geometries and/or cross-sectional areas is most optimally suited for deployment in the subject.