Personalized Basal Insulin Delivery Using Time-Based Glucose Profiles
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Solution Overview
Problem
Existing insulin delivery systems fail to account for individual variations in insulin sensitivity and blood glucose levels, leading to inconsistent diabetes management.
Innovation Solution
A diabetes management system that personalizes insulin delivery using a flash glucose monitor and a control device to generate multiple insulin delivery profiles based on user-initiated blood glucose readings, selecting a profile that approximates a target blood glucose level.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If standard insulin delivery is used, then insulin is delivered to patients, but individual variations in insulin sensitivity and blood glucose levels are not accounted for, leading to inconsistent diabetes management
Solution Approach 1:
The system generates multiple insulin delivery profiles (first, second, and third profiles) with different insulin delivery rates tailored to specific time periods (first, second, and third time periods). This allows the insulin delivery to be customized for different times of day when insulin sensitivity varies, rather than using a single uniform delivery rate.
Solution Approach 2:
The system dynamically selects between multiple pre-defined insulin delivery profiles based on current time and glucose levels. The control device automatically switches between profiles to adapt to changing physiological conditions, making the insulin delivery system flexible and responsive rather than static.
2Measurement precision
If multiple insulin delivery profiles are generated and selected based on blood glucose readings, then precise insulin delivery is achieved, but device complexity increases
Solution Approach 1:
The system divides the day into multiple discrete time periods (first, second, and third time periods) with corresponding insulin delivery profiles. This segmentation simplifies the control logic by creating distinct, manageable segments rather than requiring continuous complex calculations, making the system easier to implement while maintaining precision.
Solution Approach 2:
Multiple insulin delivery profiles are pre-calculated and stored before actual use. The control device simply needs to select the appropriate pre-computed profile based on current conditions, rather than performing complex real-time calculations. This preliminary preparation reduces the computational burden during operation.
3Reliability
If insulin delivery is personalized based on flash glucose monitor readings, then the risk of hypoglycemic and hyperglycemic events is reduced, but the ease of operation decreases due to user initiation requirements
Solution Approach 1:
The system automatically performs the complex task of selecting the appropriate insulin delivery profile based on flash glucose monitor readings and current time. Once the user initiates a flash glucose reading, the system autonomously processes the data and determines the correct insulin delivery parameters, eliminating the need for users to manually calculate or select profiles.
Data Source
AI summary
Methods of insulin delivery may include selecting a basal insulin delivery rate responsive to a projected blood glucose level that approximates a target blood glucose level. Methods of insulin delivery may further include generating insulin delivery instructions for an insulin delivery device, the insulin delivery instructions corresponding to the basal insulin delivery rate and for a variable time duration relative to an intended time duration.