Basic Copper Gluconate High Copper Loading

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Solution Overview

Problem

Copper gluconate has a lower copper loading compared to copper sulfate pentahydrate, limiting its economic and spatial use in foods and oral applications due to the need for higher loadings to achieve comparable copper content, while also being gentler on the digestive system.

Innovation Solution

Development of basic copper gluconate with a molecular formula Cu[OH][C6H11O7]—X H2O, which has a 1:1:1 metal:ligand:hydroxyl ratio and a theoretical copper content of 23.1%, achieved by neutralizing glucono delta-lactone with basic copper carbonate, resulting in a higher copper loading without sacrificing aqueous solubility or gut sensitivity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If copper gluconate is used instead of copper sulfate pentahydrate to reduce digestive system irritation, then gentleness on the digestive system is improved, but copper loading decreases

Engineering Contradiction:
Improvedigestive system irritationVSAvoidcopper loading
Core Design Contradiction:
Object-affected harmful factorsVSQuantity of substance

Solution Approach 1:

The patent changes the chemical composition parameters of copper gluconate by incorporating hydroxyl groups to form basic copper gluconate with formula Cu[OH][C6H11O7]—X H2O. This parameter change increases the copper loading from 14.4% in conventional copper gluconate to 23.1% in basic copper gluconate, while preserving the gentle digestive properties that make copper gluconate preferable to copper sulfate pentahydrate.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If higher loading of copper gluconate is used to achieve comparable copper content, then copper content level is improved, but economic efficiency and spatial utilization worsen

Engineering Contradiction:
Improvecopper content levelVSAvoideconomic efficiency
Core Design Contradiction:
Quantity of substanceVSProductivity

Solution Approach 1:

By modifying the chemical parameters of copper gluconate to create basic copper gluconate with increased copper content (23.1% vs 14.4%), the patent eliminates the need for higher loadings to achieve target copper levels. This improves economic efficiency and spatial utilization in food and beverage formulations.

Inventive Principle:
Principle #35Parameter changes

3Quantity of substance

If higher loading of copper gluconate is used to achieve comparable copper content, then copper content level is improved, but spatial utilization worsens

Engineering Contradiction:
Improvecopper content levelVSAvoidspatial utilization
Core Design Contradiction:
Quantity of substanceVSVolume of moving object

Solution Approach 1:

The patent achieves higher copper content (23.1%) through chemical parameter modification rather than increasing the physical quantity or volume of additive used. This improves spatial utilization in formulations by requiring less volume to achieve the same copper content level.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Basic copper gluconate provides a 65% higher copper content than copper gluconate, allowing for comparable copper levels with lower loadings, enhancing its economic and spatial use in formulations while maintaining gentleness on the digestive system.

Implementation Method 1

neutralizing glucono delta-lactone with basic copper carbonate, resulting in a higher copper loading

Methodology Applied
Scientific EffectNeutralization reaction: Chemical Bonding

Data Source

PatentUS11795181B2Basic copper gluconate
Publication Date: 2023.10.24 JOST CHEM
  • US11795181B2 patent drawing
  • US11795181B2 patent drawing
  • US11795181B2 patent drawing

AI summary

Basic copper gluconate having a formula of C6H12CuO8—X H2O and the structure of:The basic copper gluconate has a theoretical copper content of 23.1% (anhydrous).