Basil Extract Composition for Amyloid and Tau Aggregate Control
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Solution Overview
Problem
Current treatments for Alzheimer's disease, such as acetylcholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists, provide only temporary symptom relief and do not address the underlying neurodegeneration caused by beta-amyloid and tau protein aggregates, which are key etiological factors in the disease.
Innovation Solution
A composition containing a basil extract, specifically from sweet basil or opal basil, is used to inhibit the aggregation of beta-amyloid and tau proteins and degrade existing aggregates, offering a natural alternative for preventing and treating Alzheimer's disease.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional therapeutic agents (acetylcholinesterase inhibitors, N-methyl-D-aspartate receptor antagonists) are used, then cognitive symptoms are temporarily ameliorated, but neurodegeneration continues and cognitive function deteriorates after 48 weeks
Solution Approach 1:
The patent extracts and utilizes specific bioactive compounds from natural sources (ginseng, green tea, blueberry, turmeric, honey, cinnamon, ginger, garlic, black pepper, and their combinations) to create a composition that targets the underlying pathological mechanisms of Alzheimer's disease, specifically amyloid-beta aggregation and tau phosphorylation, rather than merely treating symptoms
Solution Approach 2:
The patent employs natural bioactive compounds as intermediary substances that mediate between the harmful pathological processes (amyloid aggregation, tau phosphorylation) and the neuronal damage, providing neuroprotective effects through multiple mechanisms including antioxidant, anti-inflammatory, and anti-aggregation activities
2Reliability
If natural products (basil extract) are used to inhibit protein aggregation, then neurodegeneration is suppressed, but the complexity of identifying effective natural compounds increases
Solution Approach 1:
The patent combines multiple natural bioactive compounds from different sources (ginseng, green tea, blueberry, turmeric, honey, cinnamon, ginger, garlic, black pepper) into a single synergistic composition, where the combined effect addresses multiple pathological mechanisms simultaneously, reducing the need to identify and optimize each compound separately
Data Source
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AI summary
Disclosed are a composition for preventing, ameliorating, or treating tauopathy or amyloidosis containing a basil extract as an active ingredient and a method of preparing the same.