BAW Sensor Passive Mixing Structures

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Solution Overview

Problem

Conventional biochemical sensing devices face limitations in consistent analyte distribution and low analyte binding rates due to laminar flow in microfluidic channels, leading to prolonged measurement times.

Innovation Solution

A fluidic device with a bulk acoustic wave (BAW) resonator structure incorporating patterned features such as protrusions and recesses in the base, wall, or cover structures to promote mixing of fluid constituents, enhancing analyte binding with functionalization material.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If laminar flow is used in microfluidic channels, then device complexity is reduced and manufacturing is simplified, but analyte distribution becomes inconsistent and binding rates decrease

Engineering Contradiction:
Improvemanufacturing simplicityVSAvoidanalyte distribution consistency
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent introduces porous mixing structures within the microfluidic channel that create controlled turbulence and enhance mixing without requiring complex external mixing mechanisms. These porous elements allow fluid to pass through while generating chaotic advection patterns that improve analyte distribution consistency.

Inventive Principle:
Principle #31Porous materials

Solution Approach 2:

The channel is segmented into multiple flow paths by introducing mixing elements such as protrusions, recesses, or baffles that divide and recombine the laminar flow. This segmentation creates multiple mixing zones that enhance analyte distribution while maintaining the overall simplicity of the device structure.

Inventive Principle:
Principle #1Segmentation

2Device complexity

If laminar flow is used in microfluidic channels, then device structure is simplified, but analyte binding rates become low and measurement time increases

Engineering Contradiction:
Improvestructural simplicityVSAvoidmeasurement speed
Core Design Contradiction:
Device complexityVSProductivity

Solution Approach 1:

The patent incorporates periodic mixing structures along the flow path that create alternating flow patterns. These periodic elements generate repeated cycles of fluid splitting and recombination, enhancing mixing efficiency and accelerating analyte binding rates without requiring complex active mixing mechanisms.

Inventive Principle:
Principle #19Periodic action

Solution Approach 2:

The mixing structures are designed to dynamically interact with the flowing fluid, creating time-varying flow patterns that enhance mixing. The geometry of protrusions and recesses is optimized to generate chaotic advection that improves mass transfer and binding kinetics while maintaining structural simplicity.

Inventive Principle:
Principle #15Dynamics

3Ease of manufacture

If conventional smooth channel walls are used, then manufacturing is easier, but fluid mixing is insufficient and analyte stratification occurs

Engineering Contradiction:
Improvefabrication simplicityVSAvoidfluid composition homogeneity
Core Design Contradiction:
Ease of manufactureVSStability of the object's composition

Solution Approach 1:

The patent introduces asymmetric mixing structures such as angled protrusions or non-symmetric baffles that create uneven flow distribution and enhance mixing. The asymmetric geometry generates vortices and chaotic flow patterns that prevent analyte stratification while maintaining compatibility with standard fabrication processes.

Inventive Principle:
Principle #4Asymmetry

Solution Approach 2:

The patent employs curved or rounded mixing elements rather than sharp angular features. The curved surfaces of protrusions or recesses create gentler flow disturbances that promote mixing while being easier to manufacture using conventional micromachining techniques. The curvature helps to eliminate dead zones and improve fluid composition homogeneity.

Inventive Principle:
Principle #14Spheroidality (Curvature)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device achieves reduced analyte stratification, increased binding rates, and shorter measurement times by facilitating mixing between fluid constituents, thereby improving the efficiency of biochemical sensing applications.

Implementation Method 1

An acoustic wave device employs an acoustic wave that propagates through or on the surface of a piezoelectric material

Methodology Applied
Scientific EffectAcoustic wave: Sound

Implementation Method 2

an acoustic wave that propagates through or on the surface of a piezoelectric material, whereby any changes to the characteristics of the propagation path affect the velocity and/or amplitude of the wave

Methodology Applied
Scientific EffectPiezoelectric effect: Piezoelectric Effect

Implementation Method 3

Conventional biochemical sensing devices face limitations in consistent analyte distribution and low analyte binding rates due to laminar flow in microfluidic channels

Methodology Applied
Scientific EffectLaminar flow: Laminar Flow

Data Source

PatentUS10371667B2BAW sensor with passive mixing structures
Publication Date: 2019.08.06 ZOMEDICA BIOTECHNOLOGIES LLC
  • US10371667B2 patent drawing
  • US10371667B2 patent drawing
  • US10371667B2 patent drawing

AI summary

A fluidic device includes a base structure, a wall structure, and a cover structure bounding a fluidic passage containing a functionalized active region of at least one bulk acoustic wave (BAW) resonator structure. One or more of the wall structure, the cover structure, or a portion of the base structure includes multiple features (e.g., protrusions and/or recesses) configured to interact with fluid flowing within the fluidic passage to promote mixing between constituents of the fluid. Methods for fabricating a fluidic device, as well as methods for biological or chemical sensing using a fluidic device, are further provided.