Benzamide Derivative Compositions for Resistant Pest Control
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Solution Overview
Problem
Existing pesticides face challenges due to insecticide resistance, high development costs, and time-consuming processes, leading to significant losses in food production and health risks from vector-borne diseases, nematode infestations, gastropod damage, and termite destruction.
Innovation Solution
Development of benzamide derivatives with pesticidal utility as acaricides, insecticides, molluscicides, and nematicides to combat pests in Phyla Arthropoda, Mollusca, and Nematoda, addressing resistance issues and improving control efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pesticides are used to control pests, then pest control is achieved, but insecticide resistance develops reducing efficacy
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of benzamide derivatives through systematic variation of substituents (R1, R2, R3, R4, R5, R6 groups) to create new molecular configurations that overcome resistance while maintaining pesticidal activity. This involves changing chemical parameters such as molecular weight, logP values, and functional group composition to develop compounds effective against resistant pest populations.
2Reliability
If new pesticides are developed to overcome resistance, then pest control efficacy is improved, but development cost and time increase
Solution Approach 1:
The patent employs preliminary action through the design of a systematic structure-activity relationship (SAR) framework that pre-establishes structure-activity relationships and guides the synthesis of benzamide derivatives. By pre-defining the core benzamide structure and systematically exploring substituent variations, the patent accelerates the discovery process and reduces the time required to identify effective compounds against resistant pests.
Solution Approach 2:
The patent applies universality by developing a series of benzamide derivatives with a common core structure that can target multiple pest species and resistance mechanisms. The systematic variation of substituents creates a family of compounds with related but distinct activities, allowing one platform to address multiple pest control challenges and reducing overall development time through shared research and development efforts.
3Reliability
If new pesticides are developed to overcome resistance, then pest control efficacy is improved, but development cost increases
Solution Approach 1:
The patent applies parameter changes by optimizing the chemical parameters of benzamide derivatives to balance efficacy and manufacturability. This involves selecting substituents that maintain high pesticidal activity while considering factors such as synthetic accessibility, availability of starting materials, and ease of purification, thereby reducing overall development costs.
4Productivity
If pesticides are applied to control pests, then crop protection is achieved, but food production losses occur due to resistance
Solution Approach 1:
The patent applies parameter changes by developing benzamide derivatives with optimized chemical parameters that restore and enhance pest control efficacy. By systematically varying molecular structure parameters, the patent creates compounds that overcome resistance and protect crops more effectively, thereby preventing food production losses.
Data Source
AI summary
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One").