Benzoyl Peroxide Microcapsule Controlled Release
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Solution Overview
Problem
Current treatments for rosacea, particularly those involving benzoyl peroxide, often cause irritation and intolerance issues due to rapid dissolution, and are only suppressive, lacking curative effects for the chronic nature of the condition.
Innovation Solution
A topical composition with benzoyl peroxide in a solid form, encapsulated as a microcapsule, with a controlled dissolution rate of less than 80% per hour, providing a slow and sustained release to reduce adverse effects and improve treatment efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If benzoyl peroxide is used in conventional formulations, then anti-acne and anti-inflammatory effects are achieved, but severe irritation and intolerance phenomena occur due to rapid dissolution
Solution Approach 1:
The benzoyl peroxide is divided into discrete microcapsules, each containing a small amount of the active ingredient. This segmentation allows controlled release of BPO over time, reducing peak concentrations that cause irritation while maintaining cumulative therapeutic effects for treating rosacea
Solution Approach 2:
The microcapsule shell acts as an intermediary between the benzoyl peroxide and the skin. It controls the dissolution rate of BPO to be less than 80% per hour, mediating the release to prevent sudden high concentrations that cause irritation while still delivering effective amounts for treatment
2Productivity
If conventional rosacea treatments are used, then suppressive effects on pustulous spasms are achieved, but curative effects are lacking due to rapid dissolution and short duration
Solution Approach 1:
The microcapsulated benzoyl peroxide provides continuous release of the active ingredient over an extended period, maintaining therapeutic levels consistently. This continuous action allows the treatment to address both acute pustulous spasms and underlying inflammatory processes, providing both suppressive and curative effects for chronic rosacea management
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The controlled release formulation significantly reduces adverse events, achieves a 30% or greater reduction in lesion count, and demonstrates a 2-grade improvement in Investigator Global Assessment, reaching clear or almost clear conditions in a higher percentage of subjects, while maintaining safety and effectiveness over prolonged use.
Implementation Method 1
wherein said solid benzoyl peroxide is encapsulated as the core of a microcapsule... the controlled release formulation significantly reduces adverse events... with a controlled dissolution rate of less than 80% per hour
Data Source
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AI summary
The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.