Benzyl Alcohol Derivative Antimicrobial Composition Synergy
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Solution Overview
Problem
Current antimicrobial agents are inadequate in effectively combating Aspergillus niger and often have issues with toxicity, stability, and odor, while seeking alternatives that are toxicologically acceptable, stable, and odorless for use in cosmetics, pharmaceuticals, and foodstuffs.
Innovation Solution
A composition comprising 4-methylbenzyl alcohol combined with 1,2-hexanediol and/or 1,2-octanediol, which synergistically enhances antimicrobial activity, providing a potent and odorless solution for preserving perishable products and treating Aspergillus niger.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antimicrobial agents are used, then antimicrobial activity is achieved, but toxicity and side effects increase
Solution Approach 1:
The patent combines 4-methylbenzyl alcohol with 1,2-alkanediols (3-14 carbon atoms) to create a synergistic antimicrobial composition. This merging of two substances achieves enhanced antimicrobial activity against Aspergillus niger while maintaining lower individual concentrations, thereby reducing toxicity compared to using single high-dose antimicrobial agents.
Solution Approach 2:
The invention creates a composite antimicrobial system by formulating 4-methylbenzyl alcohol with specific 1,2-alkanediols in defined concentration ranges (0.01-5% w/w each). This composite approach leverages the complementary properties of both substances to achieve effective antimicrobial action with improved safety profile.
2Object-affected harmful factors
If alternative antimicrobial substances are sought, then toxicological acceptability is improved, but antimicrobial effectiveness deteriorates
Solution Approach 1:
By merging 4-methylbenzyl alcohol (which has good toxicological profile) with 1,2-alkanediols (which provide additional antimicrobial activity), the composition achieves both toxicological acceptability and effective antimicrobial action against Aspergillus niger, resolving the trade-off between safety and effectiveness.
3Reliability
If higher concentrations of antimicrobial agents are used, then antimicrobial activity is enhanced, but odor increases
Solution Approach 1:
The combination allows use of lower concentrations of 4-methylbenzyl alcohol (0.01-5% w/w) while achieving effective antimicrobial activity through synergism with 1,2-alkanediols. This reduced concentration minimizes the characteristic odor of benzyl alcohol derivatives while maintaining efficacy.
Data Source
AI summary
The present invention relates to a composition comprising or consisting of: (a) one, two or more compounds selected from the group consisting of benzyl alcohol derivatives of the formula (I) wherein the substituents R1,R2, and R3 are as defined in claim 1, and (b) one, two or more compounds selected from the group consisting of: (i) branched or unbranched 1,2-alkanediols having 3 to 14 carbon atoms, (ii) benzoic acid (INCI: Benzoic Acid) and its esters and salts, (iii) 4-hydroxybenzoic acid and its esters (INCI: Parabens) and salts, (iv) 2,4-hexadienoic acid (INCI: Sorbic Acid) and its salts, (v) 2-phenoxyethanol (INCI: Phenoxyethanol) (vi) 3-iodo-2-propinyl-butylcarbamate (INCI: lodopropynyl Butylcarbamate), (vii) 3-(4-chlorphenoxy)-1,2-propane-1,2-diol (INCI: Chlorphenesin), (viii) urea (INCI: Urea) and derivatives thereof, in particular 1, 1'-methylen-bis(3-(1-hydroxymethyl-2,4-dioximidazolidin-5-yl))urea (INCI: Imidazolidinyl urea), N-hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N'- hydroxymethylurea (INCI: Diazolidinyl Urea) and N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-urea (INCI: Triclocarban), (ix) 1,3-bis-(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidindione (INCI: DMDM hydantoin), (x) 1,2-propanediol, 3-(2-ethylhexyloxy) (INCI: Octoxy glycerin), (xi) isothiazolinones and mixtures thereof (e.g. a mixture of 5-chloro-2-methyl-3(2H)-isothiazolinone and 2-methyl-3(2H)-isothiazolinone with magnesium chloride and magnesium nitrate; INCI: Methylchloroisothiazolinone and Methylisothiazolinone).