Berry Extract Composition for Measles Virus Inhibition
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Solution Overview
Problem
Current treatments for virus infections, particularly those caused by the Paramyxoviridae family such as measles, lack effective antiviral therapies, and existing medications often have toxic side effects or do not adequately address viral replication and immune response modulation.
Innovation Solution
A composition comprising extracts of black currants and bilberries, rich in anthocyanins, is used to inhibit measles virus infection and replication, with a synergistic effect achieved through a combination of monosaccharide and disaccharide anthocyanins, which targets and modulates the immune response and viral entry mechanisms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing antiviral medications are used to treat Paramyxoviridae infections, then viral replication is inhibited, but toxic side effects occur and immune response is not adequately modulated
Solution Approach 1:
The patent changes the chemical parameters by using natural anthocyanin compounds from berries instead of synthetic antiviral medications. This substitution maintains antiviral efficacy through multiple mechanisms (inhibition of viral entry, replication, and assembly) while eliminating the toxic side effects associated with conventional drugs, as the natural compounds are well-tolerated by the human body
Solution Approach 2:
The patent employs a composite approach by combining multiple anthocyanin compounds from different berry sources (black currants, bilberries, blueberries). This composite formulation creates synergistic effects that enhance antiviral activity against Paramyxoviridae while maintaining safety, as each component contributes to different aspects of viral inhibition
2Device complexity
If single anthocyanin compounds are used, then the treatment is simple, but the antiviral effect is insufficient compared to combinations
Solution Approach 1:
The patent merges multiple anthocyanin compounds from different berry sources into a single therapeutic formulation. This combination approach enhances the antiviral effect against Paramyxoviridae by targeting multiple stages of the viral lifecycle simultaneously, while the compounds are delivered together as an integrated treatment rather than separate administrations
Solution Approach 2:
The anthocyanin combination formulation achieves multi-functionality by simultaneously inhibiting viral entry, replication, and assembly processes. This single formulation addresses multiple aspects of viral pathogenesis, providing comprehensive protection against Paramyxoviridae infections without requiring multiple separate treatments
Data Source
AI summary
A composition may be used in treating or preventing a virus infection in a subject, wherein the virus is from the Paramyxoviridae family and wherein the composition includes an extract of black currants and bilberries. The composition may contain an extract from black currants and bilberries in a weight ratio in a range of from 0.5:1 to 1:0.5. The extract may be an alcoholic extract, such as a methanol extract. The composition may be administered to the subject 1 to 10 oral dosages of at least 80 mg anthocyanins each per day, preferably 3 to 6 oral dosages of at least 80 mg anthocyanins each per day. The subject may not have received a measles vaccination or have previously been exposed to the measles virus.