Antimicrobial System Using Beta Carboline and Indole Alkaloids

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Solution Overview

Problem

There is a need for antimicrobial systems that utilize naturally occurring components, which are effective, non-skin sensitizing, and environmentally sustainable, particularly for use in consumer products and on sensitive skin like that of babies.

Innovation Solution

The development of an antimicrobial system comprising a beta carboline alkaloid and an indole alkaloid, which are naturally derived from fruits and plants, and can be used in end-use formulations such as cosmetics, pharmaceuticals, and home care products, providing superior and synergistic antimicrobial benefits.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional antimicrobial components (parabens, formaldehyde donors, triclosan) are used, then antimicrobial effectiveness is improved, but skin safety and environmental sustainability deteriorate

Engineering Contradiction:

Improveantimicrobial effectivenessVSAvoidskin sensitization and environmental harm

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters by replacing traditional synthetic antimicrobials with naturally derived alkaloids (indole and beta-carboline types), fundamentally altering the chemical composition to achieve both effectiveness and safety

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs a composite antimicrobial system combining multiple naturally derived alkaloids working synergistically, where the combination of indole alkaloids and beta-carboline alkaloids provides enhanced antimicrobial activity while maintaining skin compatibility and environmental sustainability

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If naturally occurring antimicrobial components are used, then skin safety and environmental sustainability are improved, but antimicrobial effectiveness deteriorates

Engineering Contradiction:

Improveskin safety and environmental impactVSAvoidantimicrobial effectiveness

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent merges multiple naturally derived alkaloids into a single antimicrobial system, combining indole alkaloids and beta-carboline alkaloids to achieve synergistic effects that overcome the limitations of individual natural components

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composite antimicrobial formulation integrating multiple natural alkaloids, where the synergistic interaction between components enhances overall effectiveness while preserving the safety and sustainability benefits of natural ingredients

Inventive Principle:

Principle #40Composite materials

3Device complexity

If single-component antimicrobial systems are used, then formulation simplicity is improved, but antimicrobial coverage and effectiveness deteriorate

Engineering Contradiction:

Improveformulation complexityVSAvoidantimicrobial coverage

Core Design Contradiction:

Device complexityVSReliability

Solution Approach 1:

The patent segments the antimicrobial function into multiple specialized components, with different alkaloids targeting different microbial mechanisms, thereby achieving broader spectrum coverage and reduced resistance development

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent creates a multi-functional antimicrobial system where the combined alkaloid formulation provides broad-spectrum activity against bacteria, fungi, and other microorganisms, while also offering skin compatibility and environmental sustainability

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS20250151728A1Antimicrobial system with beta carboline alkaloid and indole alkaloid and compositions comprising them

Publication Date: 2025.05.15 CONOPCO INC

AI summary

Antimicrobial systems with naturally derived ingredients and compositions comprising them are described. The systems have a first ingredient comprising an indole alkaloid and a second natural ingredient that includes a beta carboline alkaloid where the systems and compositions provide superior antimicrobial benefits.