Beta-Caryophyllene Extraction Solvent for Natural Biomass

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing extraction methods using synthetic organic solvents are toxic and persist in the environment, causing health issues and environmental contamination, and are costly and time-consuming to remove from final products.

Innovation Solution

The use of beta-caryophyllene as a natural solvent for extracting target compounds such as diterpenes and triterpenes from natural biomass, which can act as a carrier, delivery adjuvant, or pharmaceutical active ingredient, reducing the need for synthetic solvents and providing a safer, more efficient extraction process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If synthetic organic solvents are used for extraction, then extraction efficiency is improved, but environmental pollution and health risks increase

Engineering Contradiction:

Improveextraction efficiencyVSAvoidenvironmental pollution and health risks

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameter of the extraction solvent from synthetic organic solvents (hexane, dichloromethane) to natural plant-based solvents (beta-caryophyllene, limonene). This parameter change maintains extraction efficiency for target compounds while eliminating the toxic residues and environmental persistence problems associated with synthetic solvents.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs natural solvents that are biodegradable and do not persist in the environment like synthetic solvents. These natural solvents can be easily removed or evaporate completely, leaving no harmful residues, thus replacing persistent synthetic solvents with transient, environmentally benign alternatives.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Reliability

If additional cleaning steps are used to remove synthetic solvents, then product safety is improved, but production cost and time increase

Engineering Contradiction:

Improveproduct safetyVSAvoidproduction process complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent converts the potential harm of solvent residues into a benefit by using natural solvents that are inherently safe and biodegradable. The solvents used (beta-caryophyllene, limonene) are recognized as safe substances that do not require extensive purification steps, thus eliminating the need for complex additional cleaning processes while ensuring product safety.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The natural solvents used in the extraction process are self-removing through their volatility and biodegradability. Beta-caryophyllene and limonene naturally evaporate or decompose without requiring additional mechanical or chemical cleaning steps, making the extraction process self-purifying and eliminating complex post-extraction treatment equipment.

Inventive Principle:

Principle #25Self-service

3Manufacturing precision

If multiple cleaning steps are implemented to remove solvent residues, then product purity is improved, but production time increases

Engineering Contradiction:

Improveproduct purityVSAvoidproduction time

Core Design Contradiction:

Manufacturing precisionVSLoss of time

Solution Approach 1:

The patent uses volatile natural solvents that completely evaporate or decompose after extraction, leaving no persistent residues. This eliminates the need for multiple time-consuming cleaning and drying steps required when using synthetic solvents, thereby maintaining product purity while significantly reducing overall production time.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method allows for the selective extraction of bioactive compounds without leaving toxic residues, producing a 100% natural product that is cost-effective and time-efficient, suitable for various health applications, including pain control and diabetes management, while avoiding the use of hazardous solvents.

Implementation Method 1

dissolving the one or more target compounds in the beta-caryophyllene extraction solvent

Methodology Applied

Scientific EffectSolvation: Solvation

Data Source

PatentUS20240216453A1Extraction of compounds with beta-caryophyllene, compositions and uses thereof

Publication Date: 2024.07.04 SYNAPTIX INC

AI summary

Provided are methods for extracting one or more target compounds, such as diterpenes, diterpenoids, triterpenes, and triterpenoids, from a natural biomass using beta-caryophyllene as an extraction solvent. Also provided are compositions comprising beta-caryophyllene, and optionally black cumin seed oil, each independently as a carrier, a delivery adjuvant, a pharmaceutical active ingredient, or any combination thereof; and a diterpene, a diterpenoid, a triterpene, a triterpenoid, or any combination thereof terpenes or triterpenes, including such compositions prepared by the methods herein. Optionally, the compositions further comprise a flavouring agent and/or one or more cannabinoids. Also provided are uses of the pharmaceutical compositions in the treatment of a disease, a disorder or a condition.