Beta-Component Magazine with Receptacles for Sterile Transfer
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Solution Overview
Problem
Existing transfer systems for barrier systems in pharmaceutical production facilities have limited capacity, requiring frequent replacement of beta components, which is inefficient and increases the risk of contamination.
Innovation Solution
A transfer system with a beta component featuring a magazine device that holds multiple objects, allowing simultaneous sterilization and efficient transfer between sterile and non-sterile areas, using a magazine device with receptacles and a centering device for precise positioning.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a single beta component is used for object transfer, then the transfer system is simple to operate, but the capacity is limited and frequent component replacement is required
Solution Approach 1:
The beta component is divided into multiple receptacles (first receptacle, second receptacle, etc.) that can be independently filled and emptied. Each receptacle can hold separate objects, allowing multiple objects to be transferred in a single beta component docking operation, thereby increasing capacity without proportionally increasing operational complexity
Solution Approach 2:
Multiple receptacles are nested within the single beta component structure. The receptacles are arranged one inside or alongside another within the beta component's volume, allowing efficient use of space and enabling multiple objects to be contained and transferred together through a single docking interface
2Productivity
If beta components are frequently replaced to transfer multiple objects, then all objects can be transferred, but the risk of contamination increases and time is lost
Solution Approach 1:
The beta component maintains continuous sterility by keeping all receptacles sealed within the single beta component structure throughout the transfer process. The beta component is sterilized once and then used to transfer multiple objects sequentially from different receptacles without requiring intermediate opening or replacement operations, thus maintaining continuous sterile barrier integrity
Solution Approach 2:
Multiple receptacles are pre-filled with different objects before docking with the alpha component. The beta component is prepared in advance with all necessary objects contained in separate sealed receptacles, allowing sequential transfer without requiring additional docking or sterilization steps during the transfer process
3Quantity of substance
If multiple beta components are used simultaneously, then object transfer capacity increases, but the complexity of operation and sterilization process increases
Solution Approach 1:
The beta component is segmented into multiple independent receptacles that can be individually accessed and emptied. This allows operators to transfer multiple objects by simply opening and removing items from different receptacles within the same beta component, avoiding the complexity of managing multiple separate beta components
Solution Approach 2:
The single beta component structure serves multiple functions by containing multiple receptacles for different objects. The same beta component can transfer various types of objects (e.g., syringes, vials, tools) through its multiple receptacles, eliminating the need for specialized beta components for each object type
Data Source
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AI summary
The invention relates to a transfer system (1) for use in a barrier system (2) and to a beta component (8) for use in a transfer system (1) and a barrier system (2) and to a production plant (3).