β-Glucan Composition for Acne and Steroid Dermatitis Relief

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Solution Overview

Problem

Current treatments for acne and steroid-dependent dermatitis are ineffective due to drug resistance, skin irritation, and imbalance of skin flora, with limited anti-inflammatory effects and long treatment cycles.

Innovation Solution

The use of β-glucan, particularly β-1,3-glucan with β-1,6-branches and a triple helix structure, for preparing compositions to prevent and treat acne and steroid-dependent dermatitis, enhancing skin immunity and providing anti-inflammatory and antibacterial effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional bactericidal drugs (antibiotics, benzoyl peroxide) are used to treat acne, then Propionibacterium acnes infection is inhibited, but drug resistance occurs and skin irritation increases

Engineering Contradiction:

Improveacne treatment efficacyVSAvoidskin irritation and drug resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses probiotics (Lactobacillus acidophilus, Bifidobacterium animalis) as intermediary organisms to treat acne. These probiotics modulate the skin microbiota ecosystem, indirectly suppressing Propionibacterium acnes through competitive exclusion and production of antibacterial substances, rather than directly killing the pathogen with conventional bactericidal drugs. This mediator approach achieves anti-acne effects while avoiding drug resistance and severe skin irritation.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the treatment parameter from direct bactericidal action to probiotic modulation of skin flora composition. By introducing beneficial bacteria that alter the microbial ecosystem parameters (diversity, composition, metabolic activity), the treatment achieves acne control through ecological balance restoration rather than aggressive pathogen elimination, reducing harmful side effects.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If bactericidal ingredients are used for acne treatment, then bacterial infection is controlled, but the ecological balance of skin surface flora is destroyed

Engineering Contradiction:

Improveanti-bacterial effectVSAvoidskin flora ecological balance

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent converts the harmful overgrowth of Propionibacterium acnes into a beneficial ecological balance by introducing probiotics. The probiotics compete with pathogenic bacteria for resources and space, producing bacteriocins and hydrogen peroxide that suppress pathogen growth while promoting a healthy diverse microbiota composition. This transforms the harmful single-dominance state into a beneficial balanced ecosystem.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The probiotic treatment enables the skin's own immune system and microbiota to control acne independently. The introduced beneficial bacteria colonize the skin, continuously producing antibacterial substances and maintaining ecological balance without requiring ongoing external intervention with strong bactericidal agents, thus preserving skin flora stability.

Inventive Principle:

Principle #25Self-service

3Reliability

If conventional acne treatments focus on bactericidal action, then bacterial infection is reduced, but anti-inflammatory effect and skin repair are limited

Engineering Contradiction:

Improveanti-bacterial efficacyVSAvoidanti-inflammatory effect and skin repair efficiency

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The probiotic treatment performs multiple functions simultaneously: (1) competitive inhibition of Propionibacterium acnes, (2) production of antibacterial substances (bacteriocins, hydrogen peroxide), (3) anti-inflammatory effects through immune modulation, and (4) promotion of skin barrier repair. This multi-functional approach overcomes the limitation of single-function bactericidal drugs.

Inventive Principle:

Principle #6Universality (Multi-functionality)

4Reliability

If topical glucocorticoids are used for dermatitis treatment, then inflammation is suppressed, but steroid-dependent dermatitis develops with long treatment cycles

Engineering Contradiction:

Improveanti-inflammatory effectVSAvoidtreatment cycle duration

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent uses probiotics as intermediary agents to modulate skin immunity and reduce inflammation without relying on glucocorticoids. The probiotics interact with the immune system to downregulate inflammatory responses through immune education and cytokine modulation, providing sustained anti-inflammatory effects without the rebound effect and dependency associated with steroid treatments.

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS12533372B2Biological polysaccharide for preventing and treating acne and steroid- dependent dermatitis and use thereof

Publication Date: 2026.01.27 BOMAN (ZHEJIANG) BIOTECHNOLOGY CO LTD

AI summary

Provided are a biological polysaccharide having the effect of preventing and treating acne and/or steroid-dependent dermatitis and the use thereof. Specifically, provided is the use of β-glucan for preparing a formulation or composition, wherein the formulation or composition is used in the prevention and/or treatment of acne and/or steroid-dependent dermatitis. The β-glucan has the effects of significantly relieving and improving acne and/or steroid-dependent dermatitis, effectively controlling the occurrence of acne and/or steroid-dependent dermatitis, accelerating the healing and/or regression of acne and/or steroid-dependent dermatitis.