β-Glucan Composition Enhancing Immune Checkpoint Antibody Efficacy
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing antibody drugs, such as immune checkpoint inhibitors, have limitations in effectively suppressing cancer growth, and there is a need to enhance their efficacy.
Innovation Solution
A composition containing β-glucans, derived from Aureobasidium pullulans or shiitake, is administered in conjunction with antibody drugs to enhance their cancer-suppressing effects through immune checkpoint inhibition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antibody drugs alone are used for immune checkpoint inhibition, then the treatment can be administered with a single agent, but the anti-cancer effect is insufficient
Solution Approach 1:
The patent combines antibody drugs with β-glucan-containing compositions to create a composite treatment formulation. This merging of two different therapeutic agents (antibody drug and β-glucan) into a single composition allows the treatment to leverage both the immune checkpoint inhibition capability of the antibody and the immunomodulatory effects of β-glucan, thereby enhancing the overall anti-cancer effect while maintaining a unified treatment approach
2Reliability
If β-glucan is added to enhance antibody drug effect, then the anti-cancer efficacy is improved, but the treatment requires combination therapy
Solution Approach 1:
The patent integrates β-glucan-containing composition with antibody drug into a single combined treatment formulation. This merging approach allows both therapeutic agents to be administered together, simplifying the treatment regimen while achieving enhanced anti-cancer efficacy through the synergistic effects of immune checkpoint inhibition and immunomodulation
Solution Approach 2:
The patent creates a composite therapeutic composition that combines two different types of therapeutic agents: antibody drugs (proteins) and β-glucan (carbohydrate polysaccharide). This composite formulation leverages the complementary mechanisms of action of both components, where the antibody drug provides specific immune checkpoint inhibition while β-glucan provides broad immunomodulatory effects, resulting in enhanced anti-cancer efficacy
Data Source
AI summary
Provided is a composition capable of enhancing the effect of an antibody drug such as an immune checkpoint inhibitor, etc. A β-glucan is used as an active ingredient of a composition for enhancing the effect of an antibody drug. This composition is used suitably for antibody drugs that have an effect of suppressing growth of cancer via immune checkpoint inhibition; e.g., antibody drugs including a monoclonal antibody to PD-L1.