Beta-Glucuronide Pro-Perfumes for Controlled Fragrance Release
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Solution Overview
Problem
The perfumery industry lacks effective compounds that can release odorant molecules in response to skin microflora or environmental bacteria, which are essential for prolonged and controlled fragrance delivery in applications like deodorants and antiperspirants, particularly for malodor control.
Innovation Solution
Development of β-glucuronide compounds that can be cleaved by specific bacteria, such as those with the β-glucuronidase enzyme, to release perfuming alcohols, thereby providing a controlled and prolonged odor benefit in perfumery compositions and consumer products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional perfumes are used, then initial fragrance effect is achieved, but fragrance evaporates prematurely and duration is short
Solution Approach 1:
The patent applies preliminary action by incorporating odorant molecules into pro-perfume compounds (such as glutamine conjugates, cysteine conjugates, or steroid derivatives) before application. These pro-perfumes are deposited on the skin in advance and remain dormant until skin microflora or environmental bacteria trigger their decomposition, releasing the odorant molecules gradually over time. This pre-positioning of fragrance precursors ensures prolonged and controlled release, addressing both the short duration and unreliable release of conventional perfumes.
2Duration of action of moving object
If pro-perfumes are used for controlled release, then fragrance duration is extended, but mechanism complexity increases
Solution Approach 1:
The patent employs self-service by designing pro-perfume compounds that automatically decompose through interaction with skin microflora or environmental bacteria already present on the skin. The system utilizes the body's own microbial ecosystem as the release trigger, eliminating the need for external control mechanisms, complex delivery systems, or additional components. The pro-perfumes self-regulate their decomposition based on the natural presence of bacteria, providing prolonged fragrance release without increasing device or system complexity.
3Duration of action of moving object
If bacterial decomposition is exploited for fragrance release, then prolonged odor benefit is achieved, but malodor control becomes challenging
Solution Approach 1:
The patent converts the harmful action of skin bacteria (which cause malodor by decomposing sweat components) into a beneficial function. By designing pro-perfume compounds that are specifically targeted to be decomposed by the same skin microflora, the invention transforms these malodor-causing bacteria into fragrance-releasing agents. The bacteria that would normally produce unpleasant odors are instead harnessed to break down pro-perfumes and release pleasant odorant molecules, thereby converting a harmful factor into a benefit while achieving prolonged odor control.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These compounds effectively release odorant molecules when in contact with skin bacteria, enhancing the fragrance delivery and malodor control in deodorants and antiperspirants, addressing the limitations of existing perfumes that often evaporate prematurely.
Implementation Method 1
compounds comprising at least one β-glucuronide moiety capable of liberating odorant molecules in particular alcohols through the action of skin microflora or of a bacteria from the environment
Implementation Method 2
cleaved by specific bacteria, such as those with the β-glucuronidase enzyme, to release perfuming alcohols
Data Source
AI summary
The present invention relates to the field of perfumery. More particularly, it concerns compounds comprising at least one β-glucuronide moiety capable of liberating a perfuming alcohol. The present invention concerns also the use of said compounds in perfumery as well as the perfuming compositions or perfumed articles, in particular deodorants or antiperspirants comprising the invention's compounds.