Beta-Hydroxybutyrate Formulation Reducing Salt Side Effects
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Solution Overview
Problem
Current administration methods for beta-hydroxybutyrate salts, such as oral or intravenous administration, often result in excessive intake of salts like sodium, magnesium, and potassium, leading to side effects like high blood pressure, stroke, and gastrointestinal issues, and polymers deliver beta-hydroxybutyrate slowly, requiring larger doses for effective ketosis promotion.
Innovation Solution
A pharmaceutically effective composition combining beta-hydroxybutyrate, cannabidiol, and other compounds, including R-beta-hydroxybutyrate, is administered in various forms like tablets, capsules, or beverages, using blends of beta-hydroxybutyrate salts and esters to reduce side effects and enhance bioavailability, allowing for faster and more sustained ketone elevation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If beta-hydroxybutyrate salts are administered orally or intravenously to promote weight loss and ketosis, then weight loss and ketosis are improved, but excessive salt intake causes harmful side effects like high blood pressure, stroke, and gastrointestinal problems
Solution Approach 1:
The patent extracts and removes the harmful salt components (sodium, magnesium, potassium) from the beta-hydroxybutyrate administration system while retaining the beneficial ketone delivery function. This is achieved by using salt-free or low-salt beta-hydroxybutyrate formulations, thereby eliminating the harmful side effects while maintaining the weight loss and ketosis promotion benefits
Solution Approach 2:
The patent changes the chemical composition parameters of the beta-hydroxybutyrate formulation by reducing or eliminating salt content. This parameter change transforms the formulation from high-salt to salt-free/low-salt, resolving the contradiction between effective ketone delivery and harmful salt intake
2Reliability
If polymers of beta-hydroxybutyrate are administered to promote ketosis, then ketosis is achieved, but delivery is slow and larger amounts must be administered
Solution Approach 1:
The patent changes the physical and chemical parameters of the beta-hydroxybutyrate formulation by using non-polymer forms or modified delivery systems that increase solubility and absorption rate. This accelerates the delivery speed of ketones to the bloodstream while maintaining effective ketosis promotion, eliminating the need for large polymer doses
Solution Approach 2:
The patent employs composite formulation strategies combining beta-hydroxybutyrate with other compounds or delivery vehicles that enhance solubility and rapid absorption. This composite approach enables fast delivery of ketones without requiring large amounts of polymer material
Data Source
AI summary
In various implementations, cannabidiol, beta-hydroxybutyrate, related compounds, and/or one or more other compounds may be administered to an individual to improve the health of the individual. The beta-hydroxybutyrate may include R-beta-hydroxybutyrate. The beta-hydroxybutyrate may include a salt and a polymer of beta-hydroxybutyrate. Other compounds may include amino acids, fatty acids or esters thereof, and/or combinations thereof.