β-Sheet Protein Crosslinking Agent With Aromatic Adsorption Groups
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Solution Overview
Problem
Conventional protein crosslinking methods require cumbersome chemical operations, leading to low productivity.
Innovation Solution
A protein crosslinking agent containing a structural unit derived from polyethylene, polyvinyl alcohol, polyamine, polyamide, or polyester, combined with a group having an aromatic ring such as benzothiazole, benzoxazole, benzimidazole, or naphthylazo, which adsorbs non-covalently to proteins with a β-sheet structure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional chemical crosslinking methods are used, then mechanical strength of protein is improved, but productivity decreases due to cumbersome chemical operations
Solution Approach 1:
The patent introduces a crosslinking agent as an intermediary substance that mediates the crosslinking process. This agent contains a polymer structural unit and a specific group that facilitates crosslinking through adsorption and chemical reaction, eliminating the need for complex chemical operations while maintaining mechanical strength improvement
Solution Approach 2:
The patent replaces conventional chemical crosslinking methods with a simplified process using a specifically designed crosslinking agent. The agent's structural units and functional groups work together to achieve crosslinking through adsorption and reaction mechanisms, substituting complex chemical procedures with a more efficient agent-based approach
2Ease of operation
If simple crosslinking agents are used, then ease of operation is improved, but mechanical strength improvement is insufficient
Solution Approach 1:
The crosslinking agent is designed as a composite structure combining a polymer structural unit (from polyethylene, polyvinyl alcohol, polyamine, polyamide, polyester, or polyether) with a specific functional group (benzothiazole, benzoxazole, benzimidazole, or naphthylazo). This composite structure provides both ease of operation and sufficient mechanical strength improvement
Solution Approach 2:
The patent applies local quality by incorporating specific functional groups (benzothiazole, benzoxazole, benzimidazole, or naphthylazo) at specific locations within the crosslinking agent structure. These groups have specific adsorption and reaction properties that enable effective crosslinking while maintaining overall simplicity of the agent
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates efficient crosslinking of proteins with improved mechanical strength and adhesion, enhancing the usability of protein-based materials in applications like biosensors and structural materials.
Implementation Method 1
since the group containing an aromatic ring adsorbs non-covalently to a protein having a β-sheet structure
Data Source
AI summary
A purpose is to provide a protein crosslinking agent which can be easily used. A protein crosslinking agent for a protein having a β-sheet structure is provided, comprising a structural unit derived from one selected from the group consisting of polyethylene, polyvinyl alcohol, polyamine, polyamide, polyester and polyether, and a group containing an aromatic ring, wherein the group containing an aromatic ring has at least one selected from the group consisting of a benzothiazole group, a benzoxazole group, a benzimidazole group and a naphthylazo group, each of which may have a substituent.