Beta-tricalcium phosphate binding peptides for stable EGF tethering

The patent introduces β-TCP binding peptides as intermediary molecules that bridge the β-TCP material and desired functional proteins. These peptides naturally bind to β-TCP surfaces and can be fused with functional proteins like EGF, enabling indirect surface modification without direct chemical modification of β-TCP. This resolves the contradiction by providing a reliable pathway to enhance surface functionality through biological rather than chemical means.

The patent creates composite structures by tethering functional proteins to β-TCP surfaces through binding peptides. This forms a composite material system where β-TCP provides the structural framework for bone void filling, while the tethered proteins enhance biological functionality. The composite approach maintains the advantageous physical properties of β-TCP for handling and bone void filling while adding enhanced bio-functionality through the protein component.

The β-TCP binding peptides serve as intermediary molecules that facilitate the tethering of additional proteins to β-TCP surfaces. These peptides have natural affinity for β-TCP and can be genetically fused with desired functional proteins, creating fusion proteins that self-assemble on β-TCP surfaces. This intermediary approach enables effective tethering without requiring direct chemical modification capabilities of β-TCP, thus resolving the contradiction between extended bio-functionality and manufacturing ease.