Automated BFS Sterilization via Sensor-Controlled Steam and Air Switching

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Solution Overview

Problem

Current sterilization processes for blow-fill-seal (BFS) machines require human intervention, which can lead to errors and contamination, and existing methods are not fully effective in maintaining sterility during production mode, especially after the filling tank is loaded with products.

Innovation Solution

A fully automated sterilization process for the product pathway of BFS machines, using a processor-controlled system that isolates the holding tank, supplies sterilizing agents like steam, and switches to filtered compressed air, while monitoring temperature and pressure to ensure sterility without human intervention.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If manual sterilization processes are used in BFS machines, then operators can adjust sterilization parameters, but human intervention introduces errors and contamination risk

Engineering Contradiction:
Improvesterilization reliabilityVSAvoidmanual operation requirement
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The sterilization system performs self-monitoring and self-adjustment through automated sensors and control mechanisms. The system automatically detects sterilization status, monitors temperature and pressure parameters, and adjusts processing conditions without requiring continuous manual intervention, thereby eliminating human error while maintaining operational control

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

Manual mechanical operations are replaced with automated electronic control systems. The patent implements computer-controlled sterilization processes that automatically manage steam injection, temperature regulation, and pressure control, substituting human-operated mechanical systems with automated electromechanical systems to improve reliability

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If steam sterilization is used for initial sterilization, then effective sterilization is achieved, but steam is not suitable for sterilization during production mode when filling tank is loaded

Engineering Contradiction:
Improvesterilization effectivenessVSAvoidsterilization applicability across different modes
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The sterilization system dynamically adapts its operation mode based on real-time detection of machine state. The system automatically switches between steam sterilization mode (for initial sterilization when filling tank is empty) and filtered air sterilization mode (during production mode when filling tank is loaded), allowing the sterilization method to change according to operational conditions without compromising effectiveness

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system changes key sterilization parameters based on operational mode. During initial sterilization, steam is injected with high temperature and pressure parameters. During production mode, the system transitions to filtered air with different temperature and flow parameters, adjusting the sterilization parameters to match the specific requirements of each operational phase

Inventive Principle:
Principle #35Parameter changes

3Reliability

If automated sterilization process is implemented, then human error is eliminated and sterility is maintained, but system complexity increases

Engineering Contradiction:
Improvesterility maintenanceVSAvoidautomation system complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The automated sterilization system is designed with multi-functional components that perform multiple operations. The control system integrates steam injection control, temperature monitoring, pressure regulation, and mode switching functions into a single unified automated system, reducing overall system complexity while maintaining comprehensive sterilization capabilities

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent introduces an automated control system as an intermediary between the sterilization components and the operational requirements. This intermediary system coordinates steam injection, air filtration, temperature control, and mode transitions, managing the complexity internally while presenting a simplified interface and ensuring reliable sterility maintenance

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This process eliminates human error, maintains a sterile environment, and ensures reliable sterilization of the product pathway, reducing the risk of contamination and maintaining aseptic conditions during production.

Implementation Method 1

supplying a sterilizing agent to the product pathway

Methodology Applied
Scientific EffectSteam sterilization: Heating

Implementation Method 2

supplying filtered compressed air to the product pathway

Methodology Applied
Scientific EffectPressure differential: Pressure Gradient

Data Source

PatentUS9533065B2Automated sterilization process integrated with a blow fill seal machine
Publication Date: 2017.01.03 WOLVERINE BIOSCIENCES LLC
  • US9533065B2 patent drawing
  • US9533065B2 patent drawing
  • US9533065B2 patent drawing

AI summary

A process and system for sterilization of a product pathway of a blow-fill-seal machine. The process comprises steps of: (1) isolating a holding tank from the product pathway; (2) supplying a sterilizing agent to the product pathway of the BFS machine when the holding tank is isolated; (3) stopping the supply of sterilizing agent to the product pathway when a threshold is reached; and (4) supplying filtered compressed air to the product pathway when the supply of sterilizing agent is stopped. The process is preferably executed automatically without human intervention once initiated. Also described is a system for carrying out the process including a processor, valves and temperature and/or pressure sensors which provide information to the processor to determine when to open and close the valves to supply sterilizing agent and/or compressed air to the product pathway or holding tank.