Bi-stable Quantum Wire Arrays via Self-Assembly

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Solution Overview

Problem

Current methods fail to effectively self-assemble biological molecules into bi-stable vertical quantum wire arrays at room temperature for high-performance quantum calculation and ultra-sensitive diagnostic applications, lacking efficient processes for creating nanometer-scale, size-controlled structures with quantum bits and Kondo effects.

Innovation Solution

The self-assembly of liquid pharmaceutical ingredients, including β-adrenergic agonists, P2-purinergic agonists, phenylalkylamine calcium channel blockers, antioxidases, and nucleic acids, into bi-stable quantum wire arrays using inelastic electron tunneling and intermolecular coordination, with specific molar ratios and cooling processes to form crystallized patterns on silicon substrates at −4°C, enabling the creation of nanometer-scale, size-controlled vertical quantum wire arrays with quantum bits and Kondo effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional self-assembly methods are used, then biological molecules can form structures, but they cannot form bi-stable vertical quantum wire arrays at room temperature with quantum bits and Kondo effects

Engineering Contradiction:
Improveformation of bi-stable quantum wire arrays with quantum bitsVSAvoidself-assembly process complexity
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent applies parameter changes by systematically varying the pH values (using buffers at pH 4.0, 5.0, 6.0, 7.0, 8.0, 9.0, 10.0), ionic strengths (0.1M, 0.2M, 0.3M, 0.4M, 0.5M NaCl), and temperatures (4°C, 25°C, 37°C, 50°C, 70°C) to optimize the self-assembly conditions. This enables the formation of bi-stable vertical quantum wire arrays with quantum bits and Kondo effects at room temperature, resolving the contradiction between reliability and ease of manufacture.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses buffer solutions as intermediaries to mediate the self-assembly process. Different buffer systems (acetate buffer, phosphate buffer, Tris buffer, borate buffer) are employed to control the chemical environment and facilitate the formation of quantum wire arrays. The buffers act as intermediaries that enable reliable structure formation while maintaining relatively simple experimental conditions.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Length of moving object

If nanometer-scale size control is achieved, then quantum wire arrays with quantum bits are formed, but the manufacturing precision requirements increase

Engineering Contradiction:
Improvenanometer-scale quantum wire array dimensionsVSAvoidsize control precision
Core Design Contradiction:
Length of moving objectVSManufacturing precision

Solution Approach 1:

The patent employs periodic action through controlled incubation time sequences (1 hour, 2 hours, 4 hours, 8 hours, 12 hours, 24 hours, 48 hours, 72 hours) to achieve nanometer-scale size control. The time-dependent self-assembly process allows gradual formation of quantum wire arrays with precise dimensions, where the periodic monitoring and adjustment of assembly conditions enable accurate control of length, width, and height parameters while maintaining manufacturing feasibility.

Inventive Principle:
Principle #19Periodic action

3Measurement precision

If multi-functional nano-devices with quantum bits and Kondo effects are created, then diagnostic sensitivity and precision improve, but device complexity increases

Engineering Contradiction:
Improvediagnostic sensitivityVSAvoidnano-device structure
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent achieves multi-functionality by integrating quantum bits, Kondo effects, and diagnostic capabilities into a single quantum wire array structure. The same self-assembled molecular framework simultaneously provides quantum computational functionality (through quantum bits), electronic transport properties (through Kondo effects), and diagnostic functionality (through target recognition). This universal design enables improved diagnostic sensitivity and precision without proportionally increasing device complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges multiple functional components into a unified quantum wire array structure. The biological molecules (peptides, proteins, nucleic acids) are combined with quantum functional elements to create an integrated system where quantum bits, charge transport pathways, and target recognition sites coexist in a single nanometer-scale structure. This merging approach enables multi-functional nano-devices that achieve high diagnostic precision while maintaining relatively simple overall architecture.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach successfully generates nanometer-scale, size-controlled, bi-stable quantum wire arrays with quantum bits and Kondo effects at room temperature, facilitating the development of high-performance quantum calculation and ultra-sensitive diagnostic tools, and enabling the creation of multi-functional nano-devices and nano-diagnostic tools with improved sensitivity and precision.

Implementation Method 1

single molecular level pharmaceutical verapamil, isoprenaline, superoxide dismutase and adenosine triphosphate to be self-assembled into bi-stable nanometer vertical quantum wire arrays

Methodology Applied
Scientific EffectSelf-assembly: Self-Assembly

Implementation Method 2

inelastic electron tunneling and intermolecular coordination along with hydrogen bonds enable single molecular level pharmaceutical verapamil, isoprenaline, superoxide dismutase and adenosine triphosphate to be self-assembled into bi-stable nanometer vertical quantum wire arrays

Methodology Applied
Scientific EffectInelastic electron tunneling:

Implementation Method 3

inelastic electron tunneling and intermolecular coordination along with hydrogen bonds enable single molecular level pharmaceutical verapamil, isoprenaline, superoxide dismutase and adenosine triphosphate to be self-assembled into bi-stable nanometer vertical quantum wire arrays

Methodology Applied
Scientific EffectIntermolecular coordination:

Implementation Method 4

inelastic electron tunneling and intermolecular coordination along with hydrogen bonds enable single molecular level pharmaceutical verapamil, isoprenaline, superoxide dismutase and adenosine triphosphate to be self-assembled into bi-stable nanometer vertical quantum wire arrays

Methodology Applied
Scientific EffectHydrogen bonds:

Implementation Method 5

bi-stable nanometer vertical quantum wire arrays that possess quantum bit operator permutations and kondo effects at room temperature

Methodology Applied
Scientific EffectKondo effects:

Implementation Method 6

crystallized patterns on silicon substrates at −4°C

Methodology Applied
Scientific EffectCrystallization: Crystallisation

Implementation Method 7

cooling processes to form crystallized patterns on silicon substrates at −4°C

Methodology Applied
Scientific EffectFreezing: Freezing

Data Source

PatentUS8574570B2Bi-stable quantum wire array of self-assembled nanomedicine and the preparation method therefor
Publication Date: 2013.11.05 ZHONGSHAN HOSPITAL FUDAN UNIV
  • US8574570B2 patent drawing
  • US8574570B2 patent drawing
  • US8574570B2 patent drawing

AI summary

A bi-stable quantum wire array of self-assembled nano-medicine and its process present in the invention. The bi-stable quantum wire array with quantum bit and kondo effect is prepared by self-assembling an oxygen radical antagonist of antioxidase, a β-receptor agonist, a P2 receptor agonist, a calcium antagonist of phenyl alkyl amines, and/or a nucleotide monomer of purines and its binary, ternary, quaternary or quinary compounds and using the interaction of inelastic electron tunneling. The invention not only benefits mechanisms-targeted multifunctional device discoveries, but also profits inventions of nanometer structures, novel materials, quantum calculation devices, biosensors and quantum bit magnetic random access memories (MRAM).