Bicyclic Compounds for Pest Control with Plant Tolerance
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Solution Overview
Problem
Current plant protection products face challenges such as limited spectrum of activity, resistance issues, toxicity concerns, and synthesis complexity, necessitating the development of new compounds with improved properties.
Innovation Solution
Bicyclic compounds of specific structural formulas, which exhibit insecticidal properties and are well-tolerated by plants, offering favorable toxicological and environmental profiles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If new bicyclic compounds are developed to broaden pesticide spectrum, then effectiveness against arthropods and insects is improved, but synthesis complexity and manufacturing effort increase
Solution Approach 1:
The bicyclic compound structure is divided into distinct functional regions (first cyclic structure with nitrogen, second cyclic structure, linker L1/L2/L3). This segmentation allows independent optimization of each module for pest effectiveness while maintaining manageable synthesis pathways for each component.
Solution Approach 2:
The patent systematically varies key structural parameters including the type of cyclic structures (saturated/unsaturated), linker compositions (L1-L3 with different atoms and bonds), and substituent patterns (R1-R6 groups). These parameter changes enable tuning of both pest effectiveness and synthesis feasibility across the compound series.
2Duration of action of stationary object
If pesticide spectrum is broadened to address resistance issues, then duration of action is improved, but toxicity concerns may increase
Solution Approach 1:
Different regions of the bicyclic molecule have specialized functions: the nitrogen-containing cyclic structure provides pest target interaction for effectiveness, while specific substituent groups (R1-R6) and linker compositions modulate toxicity and environmental fate. This local quality differentiation allows simultaneous optimization of duration of action and safety profile.
Solution Approach 2:
The bicyclic compound combines multiple structural elements (two cyclic systems, heteroatoms, variable linkers, substituents) into a composite molecular architecture. This composite structure integrates pest efficacy functions with reduced toxicity characteristics, achieving prolonged protection while minimizing harmful effects on non-target organisms.
3Object-affected harmful factors
If compound structure is optimized for plant tolerance, then environmental compatibility is improved, but spectrum of activity may be limited
Solution Approach 1:
The bicyclic compound structure is designed with universal features that provide both plant tolerance and broad-spectrum pest activity. The nitrogen-containing cyclic core offers inherent safety for cultivated plants while the variable substituents (R1-R6) and linkers (L1-L3) enable activity against diverse arthropod and insect pests across multiple taxonomic groups.
Data Source
AI summary
The invention relates to novel bicyclic compounds, to agents containing said compounds, to the use thereof for controlling animal pests and to methods and intermediate products for the production thereof.