Bi-directional Flow Sensor for Nitric Oxide Delivery

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Solution Overview

Problem

Delivering accurate and precise doses of nitric oxide to patients using ventilator-associated breathing circuits is challenging due to inconsistent and unknown flow profiles, leading to potential overdosing or underdosing, which affects safety and efficacy.

Innovation Solution

A bi-directional breathing circuit gas flow sensor is integrated into the nitric oxide delivery system to measure both forward and reverse flows, enabling precise control of nitric oxide delivery by compensating for reverse flow and ensuring accurate dosing through algorithms that adjust delivery based on measured flow patterns.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If nitric oxide is injected into breathing gas with unknown flow profiles, then nitric oxide can be delivered to patients, but accurate and precise dosing cannot be ensured

Engineering Contradiction:
Improvenitric oxide dose accuracyVSAvoidbreathing gas flow measurement
Core Design Contradiction:
Quantity of substanceVSMeasurement precision

Solution Approach 1:

The system employs a bi-directional flow sensor to continuously monitor breathing gas flow and provides real-time feedback to the control module. This feedback enables the system to dynamically adjust nitric oxide delivery based on actual flow conditions, ensuring accurate dosing despite variable breathing patterns and ventilator types.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent replaces traditional mechanical flow measurement methods with electronic flow sensing and digital signal processing. The bi-directional flow sensor uses electronic detection to measure gas flow in both directions, and the control module uses algorithms to process this data and adjust delivery accordingly, improving measurement precision and reliability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Ease of operation

If nitric oxide is delivered based on assumed constant flow, then delivery is simplified, but reverse flow causes overdosing or underdosing

Engineering Contradiction:
Improvedelivery control simplicityVSAvoiddosing accuracy
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The system transitions from static, assumption-based delivery control to dynamic, real-time control. The bi-directional flow sensor continuously monitors actual gas flow conditions, and the control module dynamically adjusts nitric oxide delivery based on measured forward and reverse flow patterns, maintaining both simplicity and reliability.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system changes the operational parameters of delivery control by incorporating real-time flow measurement data. Instead of relying on fixed delivery rates, the system continuously adapts delivery parameters based on actual breathing circuit gas flow conditions, including detection and compensation of reverse flow events.

Inventive Principle:
Principle #35Parameter changes

3Quantity of substance

If bi-directional flow measurement is implemented, then dosing accuracy is improved, but device complexity increases

Engineering Contradiction:
Improvenitric oxide dosing precisionVSAvoidflow measurement system complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The bi-directional flow sensor serves multiple functions: it measures forward flow, detects reverse flow, provides real-time feedback, and enables various delivery control strategies. This multi-functionality reduces the need for separate sensors and control mechanisms, thereby limiting the increase in device complexity while achieving improved dosing precision.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS11471641B2Systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement
Publication Date: 2022.10.18 MALLINCKRODT PHARMACEUTICALS IRELAND LTD
  • US11471641B2 patent drawing
  • US11471641B2 patent drawing
  • US11471641B2 patent drawing

AI summary

The present invention generally relates to systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement. At least some of these enhanced BCG flow measurements can be used to address some surprising phenomena that may, at times, occur when wild stream blending therapeutic gas into breathing gas that a patient receives from a breathing circuit affiliated with a ventilator. Utilizing at least some of these enhanced BCG flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives from a ventilator can at least be more accurate and/or over delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.