Bifidobacterium CP-9 Probiotic Culture for Calcium Absorption

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Solution Overview

Problem

Current methods for increasing calcium absorption are inadequate, particularly in individuals with calcium deficiency-associated disorders, as calcium supplements may not be effectively absorbed due to vitamin D deficiency and can lead to kidney stone risks with excessive use.

Innovation Solution

Administering a composition containing a culture of Bifidobacterium animalis subsp. lactis CP-9, which is deposited under the Budapest Treaty, to enhance calcium absorption by increasing vitamin D receptor expression and calcium ion transport in intestinal cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If calcium supplements are used to increase calcium intake, then calcium absorption is improved, but kidney stone risk increases due to excessive urinary calcium levels

Engineering Contradiction:

Improvecalcium absorptionVSAvoidkidney stone risk

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent introduces probiotics (specifically Lactobacillus casei, Bifidobacterium animalis, and Streptococcus thermophilus) as intermediary substances that mediate calcium absorption in the intestine. These probiotics produce substances that enhance calcium uptake without causing excessive urinary calcium excretion, thereby resolving the contradiction between improving calcium absorption and preventing kidney stone formation

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the mechanism parameter from direct calcium supplementation to probiotic-mediated calcium absorption. By using live microbial dietary supplements that produce calcium-absorbing substances, the patent transforms the absorption pathway to achieve better calcium uptake while maintaining safer urinary calcium levels

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If calcium supplements are used to treat calcium deficiency, then calcium intake is increased, but absorption effectiveness decreases due to vitamin D deficiency

Engineering Contradiction:

Improvecalcium intakeVSAvoidabsorption effectiveness

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent uses probiotics as intermediary organisms that produce substances capable of enhancing calcium absorption independently of vitamin D. The probiotics (Lactobacillus casei, Bifidobacterium animalis, Streptococcus thermophilus) generate metabolites that facilitate calcium transport across the intestinal barrier, bypassing the vitamin D dependency that limits conventional calcium supplement effectiveness

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If conventional probiotics are used to restore intestinal microflora balance, then intestinal immunity and digestion are regulated, but calcium absorption enhancement is insufficient

Engineering Contradiction:

Improveintestinal microflora balanceVSAvoidcalcium absorption

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent selects probiotic strains that perform multiple functions: they restore intestinal microflora balance (original function) and simultaneously enhance calcium absorption (additional function). The chosen probiotics (Lactobacillus casei, Bifidobacterium animalis, Streptococcus thermophilus) exhibit both probiotic effects on gut health and specific calcium-absorbing capabilities, achieving dual benefits in one intervention

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The use of Bifidobacterium animalis subsp. lactis CP-9 significantly increases calcium absorption by enhancing vitamin D receptor expression and calcium ion transport, effectively addressing calcium deficiency-related disorders while minimizing the risk of kidney stones.

Implementation Method 1

The culture of Bifidobacterium animalis subsp. lactis CP-9 can increase the expression of vitamin D receptor and calcium ion transport in intestinal cells

Methodology Applied

Scientific EffectVitamin D receptor expression enhancement:

Implementation Method 2

The culture of Bifidobacterium animalis subsp. lactis CP-9 can increase the expression of vitamin D receptor and calcium ion transport in intestinal cells

Methodology Applied

Scientific EffectCalcium ion transport:

Data Source

PatentUS20240316127A1Method for increasing calcium absorption using culture of bifidobacterium animalis subsp. lactis CP-9

Publication Date: 2024.09.26 GLACT BIOTECH

AI summary

A method for increasing calcium absorption includes administering to a subject in need thereof a composition containing a culture of Bifidobacterium animalis subsp. lactis CP-9. The Bifidobacterium animalis subsp. lactis CP-9 is deposited under the Budapest Treaty at the China Center for Type Culture Collection (CCTCC) under an accession number CCTCC M 2014588.