Bifidobacterium Lysate and Mannose Promote Cutibacterium acnes Growth
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Solution Overview
Problem
Current cosmetic compositions that include Bifidobacterium species lysate and Saccharomyces genus yeast extract do not effectively promote the growth of Cutibacterium acnes, a beneficial skin bacterium, which is reduced with aging and provides antioxidant properties, leading to skin aging and oxidative stress issues.
Innovation Solution
A cosmetic composition comprising a Bifidobacterium species lysate, an extract of yeast from the Saccharomyces genus, and a monosaccharide such as mannose or rhamnose, which together promote the specific growth of Cutibacterium acnes, addressing skin aging and oxidative stress.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional cosmetic compositions use Bifidobacterium species lysate and Saccharomyces genus yeast extract alone, then the composition provides basic skin care benefits, but the growth promotion of Cutibacterium acnes is insufficient
Solution Approach 1:
The patent combines three specific ingredients (Bifidobacterium species lysate, Saccharomyces genus yeast extract, and mannose or rhamnose) into a unified cosmetic composition that synergistically promotes Cutibacterium acnes growth. The combination of these three components creates an enhanced effect that neither the individual ingredients nor simpler combinations can achieve alone, directly resolving the contradiction between effectiveness and complexity.
Solution Approach 2:
The patent creates a composite cosmetic formulation integrating multiple bioactive components with complementary functions. The Bifidobacterium lysate provides antioxidant benefits, the yeast extract contributes nutritional factors, and the monosaccharides (mannose/rhamnose) serve as specific growth promoters for Cutibacterium acnes. This composite approach maximizes the growth promotion effect while maintaining formulation stability.
2Quantity of substance
If the composition includes multiple ingredients to promote Cutibacterium acnes growth, then the growth promotion effect is enhanced, but the formulation complexity increases
Solution Approach 1:
The patent optimizes specific parameters including the selection of particular monosaccharides (mannose or rhamnose) and their concentrations in combination with the lysate and yeast extract. By carefully controlling these compositional parameters, the formulation achieves maximum growth promotion effect with a defined, optimized ingredient set rather than attempting to include all possible growth-promoting substances.
3Quantity of substance
If Cutibacterium acnes abundance is reduced due to aging, then skin antioxidant protection decreases, but adding growth promoters alone does not sufficiently restore beneficial bacteria levels
Solution Approach 1:
The patent addresses the age-related decline of Cutibacterium acnes by converting the aging process's negative impact into an opportunity. The formulation uses Bifidobacterium lysate (which has antioxidant properties) combined with specific growth promoters to not only restore beneficial bacteria levels but also provide direct antioxidant protection, thereby converting the aging-related loss into a chance to enhance both colonization and protective functions.
Solution Approach 2:
The cosmetic composition performs multiple functions simultaneously: it promotes Cutibacterium acnes growth through the yeast extract and monosaccharides, provides antioxidant protection through the Bifidobacterium lysate and RoxP enzyme activity, and addresses age-related skin changes. This multi-functional approach resolves the contradiction by treating both the bacterial abundance issue and the oxidative stress issue with a single integrated formulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly increases Cutibacterium acnes growth, effectively preventing and treating skin aging signs and protecting against oxidative stress, offering enhanced skin care benefits.
Implementation Method 1
the combination of a Bifidobacterium species lysate, an extract of yeast of the Saccharomyces genus, and a monosaccharide chosen from mannose and/or rhamnose makes it possible to promote a growth of Cutibacterium acnes
Implementation Method 2
Cutibacterium acnes, by virtue of the secretion of a RoxP (radical oxygenase of Propionibacterium acnes) enzyme is also known to have antioxidant properties
Data Source
AI summary
The present invention relates to a cosmetic composition comprising, in a physiologically acceptable medium: —at least one microorganism of the Bifidobacterium species genus and/or a fraction thereof and/or a metabolite thereof, and —at least one extract of yeast of the Saccharomyces genus, and —at least one monosaccharide chosen from mannose, rhamnose and mixtures thereof, said microorganism being used in the form of a lysate. The present invention also relates to a cosmetic treatment process comprising the application of said composition to the skin; and also the cosmetic uses thereof.