Bifunctional Dextrin Grafting for High Embedding and Rapid Absorption

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Solution Overview

Problem

Natural active substances in food products face challenges with stability, absorption, and flavor masking due to poor solubility and embedding capabilities of β-cyclodextrin, while highly-branched cyclodextrin offers rapid absorption but lacks ideal embedding effects.

Innovation Solution

A bifunctional dextrin is prepared by grafting β-cyclodextrin onto highly-branched cyclodextrin using polyacrylic acid as a cross-linking agent, enhanced through alkali and high-pressure treatments to improve embedding capacity and absorption efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If β-cyclodextrin is used for embedding natural active substances, then embedding capacity and stability are improved, but solubility and absorption rate deteriorate

Engineering Contradiction:

Improveembedding capacityVSAvoidsolubility

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent combines β-cyclodextrin with highly-branched cyclodextrin through grafting to create a composite structure that merges the embedding capacity of β-cyclodextrin with the solubility and rapid absorption characteristics of highly-branched cyclodextrin

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite material consisting of β-cyclodextrin grafted onto highly-branched cyclodextrin backbone, utilizing the complementary properties of both components to achieve both high embedding capacity and rapid solubility

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If highly-branched cyclodextrin is used, then solubility and absorption rate are improved, but embedding capacity deteriorates

Engineering Contradiction:

ImprovesolubilityVSAvoidembedding capacity

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Inventive Principle:

Principle #40Composite materials

3Productivity

If traditional free radical initiation with Ce(IV) ions is used for grafting, then grafting efficiency is improved, but production cost deteriorates

Engineering Contradiction:

Improvegrafting efficiencyVSAvoidproduction cost

Core Design Contradiction:

ProductivityVSEase of manufacture

Solution Approach 1:

The patent replaces expensive Ce(IV) ions with inexpensive sodium periodate as the oxidizing agent for grafting, significantly reducing production cost while maintaining effective grafting efficiency

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The invention changes the chemical parameter of the oxidizing agent from Ce(IV) ions to sodium periodate, altering the reaction system to achieve cost-effective grafting while preserving functional efficiency

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The bifunctional dextrin achieves an ideal embedding effect for natural active substances, enhances nutritional value, and supports rapid energy replenishment and anti-inflammatory functions, offering improved industrial scalability and cost-effectiveness.

Implementation Method 1

The characteristics of 'hydrophobic on the inside and hydrophilic on the outside' and the unique cavity structure make the β-cyclodextrin have a relatively excellent embedding effect on natural active substances

Methodology Applied

Scientific EffectHydrophobic embedding: Absorption (physical)

Implementation Method 2

the highly-branched cyclodextrin shows strong water solubility and is easily decomposed by α-amylase, and then quickly converted into small-molecular saccharides in the intestinal tract

Methodology Applied

Scientific EffectEnzymatic hydrolysis: Enzyme

Implementation Method 3

A bifunctional dextrin is prepared by grafting β-cyclodextrin onto highly-branched cyclodextrin using polyacrylic acid as a cross-linking agent

Methodology Applied

Scientific EffectCross-linking: Chemical Bonding

Implementation Method 4

enhanced through alkali and high-pressure treatments to improve embedding capacity and absorption efficiency

Methodology Applied

Scientific EffectAlkali modification: Chemical Bonding

Implementation Method 5

enhanced through alkali and high-pressure treatments to improve embedding capacity and absorption efficiency

Methodology Applied

Scientific EffectHigh-pressure treatment: Pressure Increase

Data Source

PatentUS20230340163A1Preparation Method of Bifunctional Dextrin with High Embedding Rate and Rapid Absorption

Publication Date: 2023.10.26 QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES)

AI summary

The present disclosure relates to a preparation method of a bifunctional dextrin with a high embedding rate and rapid absorption. The preparation method includes the following steps: conducting an alkali treatment: adding 10 g of a highly-branched cyclodextrin into a 250 mL Erlenmeyer flask, adding 100 mL of a 2 mol/L NaOH solution, and conducting a treatment in a water bath at 30° C. for 1 h; conducting a high-pressure treatment; mixing materials: adding a cross-linking agent polyacrylic acid and a catalyst sodium dihydrogen phosphate, adding β-cyclodextrin, immersing while stirring for 30 min, and drying; conducting stepwise heating: heating an obtained mixed material in an oven at 90° C. for 15 min, heating to 160° C., and treating for 10 min; and conducting product acquisition: stopping heating, rinsing an obtained heated product with distilled water, conducting filtering to remove impurities, washing twice with 50° C. distilled water, drying, and collecting a resulting finished product.