Conjugated Bile Acid Biomarkers for Monitoring Mood Disorder Response
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Solution Overview
Problem
Current methods for diagnosing and treating mood disorders rely heavily on subjective assessments and combination therapies, lacking a reliable biochemical tool to detect mood disorder status and treatment efficacy.
Innovation Solution
The use of glycine-conjugated bile acids as biomarkers to detect and quantify mood disorder improvements, combined with a probiotic composition for treatment, where increased levels of cholic acid and chenodeoxycholic acid and decreased levels of ursodeoxycholic acid indicate improved mood disorder status, and administration of a probiotic with glycine or derivatives to ameliorate mood disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If subjective assessments and combination therapies are used for diagnosing and treating mood disorders, then treatment coverage can be broad, but diagnostic precision and treatment efficacy monitoring are insufficient
Solution Approach 1:
The patent replaces subjective clinical assessments with objective biochemical measurements of bile acid levels in body fluids. This substitution transforms the diagnostic process from a mechanical/subjective evaluation system to a quantitative biochemical analysis system, thereby improving diagnostic precision without increasing therapy complexity
Solution Approach 2:
The patent introduces bile acid levels as an intermediary biomarker that mediates between the probiotic treatment and the mood disorder status. This intermediary provides an objective, measurable indicator that reflects treatment efficacy, allowing for precise monitoring without requiring complex combination therapies
2Reliability
If validated self-rated scales are used to monitor treatment responses, then patient feedback can be captured, but objective biochemical monitoring is lacking
Solution Approach 1:
The patent supplements or replaces subjective self-rated scale assessments with objective biochemical measurements of bile acid levels. This substitution captures physiological information that is lost in subjective reporting, thereby improving treatment monitoring reliability while preventing loss of objective biochemical information
Solution Approach 2:
The patent establishes a feedback mechanism where bile acid levels serve as quantitative indicators of treatment efficacy. This biochemical feedback loop provides reliable, objective information about treatment response, enabling more accurate monitoring compared to subjective scales alone
3Adaptability or versatility
If multiple diagnostic and treatment approaches are combined, then comprehensive care can be provided, but simplicity and ease of operation are reduced
Solution Approach 1:
The patent extracts the key diagnostic information from complex combination therapies by focusing on a specific biochemical marker (bile acid levels). This extraction simplifies the diagnostic process while maintaining treatment versatility, as the biomarker can monitor response to various probiotic interventions without requiring multiple assessment tools
Data Source
AI summary
The present invention relates to the use of glycine-conjugated bile acids as biomarker for detecting and/or quantifying improvements of the mood disorder status and/or excessive emotional reaction of a subject. It also relates to a method for detecting and/or quantifying mood disorder, improvements of the mood disorder status and/or excessive emotional reaction of a subject, in particular for monitoring the progress of an intervention to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject, wherein the intervention comprises the administration of a probiotic. It also relates to an improved method to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject in need, comprising administering to the subject, an effective amount of a composition combining a probiotic with glycine or derivative thereof.