Bio-fermented Sodium Hyaluronate Polymer Matrix Stability
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Solution Overview
Problem
Current sodium hyaluronate polymer matrix formulations face challenges in maintaining high concentrations due to instability, leading to reduced effectiveness in wound healing and drug delivery, and are limited by the use of animal-derived sources that can cause allergies and disease transmission.
Innovation Solution
Development of stable polymer matrix compositions using bio-fermented sodium hyaluronate from bacterial sources like Streptococcus zooepidemicus or Bacillus subtilis, combined with non-ionic polymers, methylparaben, and polyethylene glycol, ensuring a concentration range of 1.5% to 3.5% w/w and improved stability and safety.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If sodium hyaluronate is obtained from animal sources (rooster combs), then formulations can be manufactured, but they cause allergies and carry risks of transmitting animal diseases to humans
Solution Approach 1:
The patent extracts the harmful animal-derived components and replaces them with bio-fermented sodium hyaluronate produced through bacterial fermentation processes, eliminating allergy and disease transmission risks while maintaining the therapeutic benefits of sodium hyaluronate in polymer matrix formulations
Solution Approach 2:
The patent changes the source parameter of sodium hyaluronate from animal origin to bacterial fermentation origin, fundamentally altering the biological source while preserving the functional properties of sodium hyaluronate in wound healing and drug delivery applications
2Quantity of substance
If sodium hyaluronate concentration is increased above 1.5% w/w, then therapeutic effectiveness is improved, but formulation stability deteriorates and viscosity becomes too high for normal use
Solution Approach 1:
The patent creates a composite polymer matrix system combining sodium hyaluronate with other compatible polymers and excipients that work synergistically to maintain formulation stability at high sodium hyaluronate concentrations (1.5-3.5% w/w) while controlling viscosity for practical application
Solution Approach 2:
The patent optimizes multiple formulation parameters including pH, ionic strength, and polymer ratios to enable stable high-concentration sodium hyaluronate formulations that maintain appropriate viscosity and stability characteristics
3Quantity of substance
If sodium hyaluronate concentration is increased above 1.5% w/w, then therapeutic effectiveness is improved, but viscosity becomes too high for normal use in tube packaging
Solution Approach 1:
The patent develops a composite formulation system that balances high sodium hyaluronate concentration with other polymers and viscosity-modifying agents to achieve a product that is both therapeutically effective and easy to apply from tube packaging
Solution Approach 2:
The patent adjusts formulation parameters including polymer molecular weight, concentration ratios, and pH to optimize the viscosity profile, ensuring the product remains pumpable and applicable despite high active ingredient content
4Productivity
If high concentration sodium hyaluronate formulations are not manufactured properly, then formulation can be produced initially, but they quickly break down resulting in very short shelf life
Solution Approach 1:
The patent implements preliminary stabilization measures during manufacturing including controlled mixing sequences, pH adjustment, and incorporation of stabilizing excipients that prevent subsequent degradation and extend shelf life of high-concentration formulations
Solution Approach 2:
The patent incorporates stabilizing agents and optimizes formulation composition beforehand to cushion against degradation mechanisms, ensuring long-term stability and preventing breakdown during storage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bio-fermented sodium hyaluronate polymer matrix compositions demonstrate enhanced stability, reduced cytotoxicity, and improved wound-healing properties, maintaining effective sodium hyaluronate levels over time, and ensuring safer, more effective topical and transdermal delivery of active ingredients.
Implementation Method 1
Fractions of HA, including its sodium salt, are known to form a stable polymer matrix when combined with a non-ionic polymer such as hydroxyethyl cellulose or hydroxypropyl cellulose
Implementation Method 2
a sodium hyaluronate polymer matrix formulation helps to maintain a moist wound environment
Data Source
AI summary
The present invention relates to stable polymer matrix compositions comprising high concentrations (from about 1.5% w/w to about 3.5% w/w) sodium hyaluronate obtained from a Streptococcus zooepidemicus source and a non-ionic polymer. The polymer matrix composition further comprises polyethylene glycol and methylparaben, and utilizes ingredients that are of pharmaceutical or compendial grade. The polymer matrix compositions may optionally comprise an active ingredient. The present polymer matrix compositions may be used in the treatment of wounds, burns, certain dermatological conditions, vaginal dryness, and in topical, transdermal delivery and sustained release of active ingredients.