Bioabsorbable Left Atrial Appendage Closure With Porous Endothelialization
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Solution Overview
Problem
Current treatment methods for minimizing thrombus migration from the left atrial appendage into the general circulation often introduce foreign matter that can provoke an inflammatory response, necessitating a percutaneous treatment option that does not result in long-term foreign matter introduction.
Innovation Solution
A bioabsorbable left atrial appendage closure device comprising a centrally joined umbrella-like support structure with a bioabsorbable porous membrane that includes a tissue growth promoting component, designed to be deployed within the left atrial appendage to retain thrombi and promote endothelialization, minimizing the release of particulate material.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatment methods (barrier devices, filter devices, surgical closure) are used to prevent thrombus migration from the left atrial appendage, then thrombus migration is effectively blocked, but foreign matter is introduced into the body which may provoke an inflammatory response and require long-term presence
Solution Approach 1:
The patent employs a porous membrane as the closure device that allows tissue ingrowth while maintaining thrombus prevention functionality. The porous structure enables endothelialization and tissue integration, allowing the device to become part of the natural tissue architecture rather than remaining as foreign matter, thereby reducing inflammatory response while maintaining reliability
Solution Approach 2:
The patent utilizes shape memory polymers that change their physical parameters (shape, stiffness) in response to temperature changes. The device is delivered in a compressed state at body temperature, then transforms to its predetermined expanded shape when exposed to cooling, enabling effective closure while minimizing trauma during deployment
2Object-affected harmful factors
If a percutaneous treatment option is used to avoid foreign matter introduction, then inflammatory response is reduced, but effective thrombus retention and tissue integration may be compromised
Solution Approach 1:
The patent employs composite materials combining shape memory polymer with porous structure and tissue growth promoting components. This composite approach enables the device to simultaneously achieve biocompatibility (reduced inflammation), mechanical functionality (thrombus retention), and biological integration (tissue ingrowth) through the synergistic combination of different material properties
Solution Approach 2:
The device incorporates tissue growth promoting components that actively encourage endothelialization and tissue ingrowth into the porous structure. This self-service mechanism allows the device to facilitate its own integration into native tissue, ensuring long-term effectiveness without requiring additional surgical interventions or leaving permanent foreign matter
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively prevents thrombus migration while promoting tissue growth, reducing the risk of inflammatory responses and ensuring controlled bioabsorption without leaving foreign material in the body.
Implementation Method 1
the plurality of bioabsorbable struts is formed from a shape memory polymer and has a delivery configuration and a deployed configuration
Implementation Method 2
the pores of the porous membrane are sized and adapted to retain thrombi within the left atrial appendage
Implementation Method 3
the porous membrane includes a tissue growth promoting component
Implementation Method 4
the plurality of bioabsorbable struts and the porous membrane are formed from a bioabsorbable polymer
Data Source
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AI summary
The disclosure pertains to percutaneously deliverable bioabsorbable closure devices for an ostium of a left atrial appendage which devices promote endothelialization across the ostium and then are bioabsorbed to leave little or no foreign residue, methods of manufacturing such bioabsorbable closure devices, and the use thereof.