Bioabsorbable Gasket for Percutaneous Heart Valve Sealing
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Solution Overview
Problem
Percutaneous heart valve implantation methods face challenges with leakage and stroke risk due to mismatch between circular/cylindrical valves and diseased vessels, particularly in the initial weeks and months post-implantation.
Innovation Solution
A percutaneous prosthetic heart valve assembly featuring a radially expandable anchor docking member and a bioabsorbable gasket made of polymer material, which expands to fit the vessel, securely engaging an implantable heart valve and degrading over time to prevent migration and leakage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a percutaneous valve implantation is performed, then the invasiveness is reduced and recovery is faster, but the risk of leakage and stroke increases due to mismatch between circular valve and diseased vessel
Solution Approach 1:
A bioabsorbable gasket is deployed ahead of the valve implant to pre-seal the mismatch gap between the circular valve and diseased vessel. The gasket is positioned first, then the valve is implanted over it, creating a preliminary seal that prevents leakage before the valve is fully deployed
Solution Approach 2:
The bioabsorbable gasket serves as an intermediary element between the circular valve and the irregularly shaped diseased vessel. It fills the geometric mismatch and creates a sealing interface, mediating the compatibility between the two components
2Reliability
If a fixed structural gasket is used to seal the valve-vessel interface, then leakage is prevented, but the device complexity and long-term foreign body burden increase
Solution Approach 1:
The gasket is designed to be temporary rather than permanent. It performs its sealing function during the critical initial period after implantation, then progressively degrades and is absorbed by the body, eliminating the need for long-term retention and reducing foreign body burden
Solution Approach 2:
The gasket material undergoes parameter changes over time, transitioning from an intact sealing structure to a degrading state, and finally to complete absorption. This temporal parameter change allows the gasket to provide sealing when needed and disappear when no longer required
3Stability of the object's composition
If the valve is securely anchored to prevent migration, then positioning stability is improved, but the ability to reposition or remove the valve is reduced
Solution Approach 1:
The anchoring system transitions from a dynamic state during implantation (where the valve can be positioned and adjusted) to a stable state after deployment (where the valve is secured against migration). The expandable anchor provides initial securement while maintaining the possibility of controlled manipulation during the deployment process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution reduces the risk of leakage and stroke by securely anchoring the prosthetic valve to the vessel, minimizing initial post-implantation risks and allowing for repositioning or removal, while the bioabsorbable gasket ensures long-term stability and integration with the body.
Implementation Method 1
the bioabsorbable gasket member comprising a bioabsorbable polymer material
Data Source
AI summary
A percutaneous prosthetic heart valve assembly comprising a radially expandable anchor docking member, the anchor docking member having an unexpanded state and an expanded state, in the expanded state, the anchor docking member comprising a mechanism for receiving and engaging an implantable heart valve and a bioabsorbable gasket member disposed about the anchor docking member, the bioabsorbable gasket member comprising a bioabsorbable polymer material, the bioabsorbable gasket member having an unexpanded and an expanded state.