Bioabsorbable Granular Substrate for Adipose Tissue Regeneration
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Solution Overview
Problem
Conventional breast reconstruction methods, such as using silicone implants or transplanting adipose tissue, face challenges in achieving large volume regeneration with normal shape and ease of implantation, especially in areas affected by breast cancer treatment, where radiation therapy hardens the skin and requires large incisions.
Innovation Solution
An adipose tissue regeneration substrate comprising bioabsorbable granular bodies with inner spaces and openings, wrapped in a bag-shaped bioabsorbable material, allowing for easy implantation and maintaining shape, as cells proliferate on the scaffold surfaces, and the substrate is absorbed once tissue regeneration is complete.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Volume of moving object
If the member for breast reconstruction is made larger to treat large resection areas, then the treatment coverage is improved, but the moldability and tissue regeneration performance deteriorate
Solution Approach 1:
The invention divides the large reconstruction volume into multiple small granular bodies (each 5-50mm in diameter). These granular bodies are packed into a bag-shaped body that maintains the overall shape. The segmentation allows each small granular body to effectively support tissue regeneration while the collective arrangement achieves large volume reconstruction with proper shape control.
2Volume of moving object
If multiple small members for breast reconstruction are placed to treat large resection areas, then the treatment coverage is improved, but the ease of implantation deteriorates due to required large incisions
Solution Approach 1:
The invention merges multiple granular bodies into a single composite structure by packing them together within a bag-shaped body. This combined structure can be implanted as one unit through a single incision, eliminating the need for multiple separate implantations through multiple large incisions, while still achieving large volume reconstruction.
Solution Approach 2:
The granular bodies are nested within the bag-shaped body, creating a hierarchical structure. The bag-shaped body acts as an outer container that holds and positions the inner granular bodies. This nesting allows the multiple granular bodies to be delivered together through a single incision while maintaining their individual regenerative functions.
3Volume of moving object
If the member for breast reconstruction is made larger, then the treatment coverage is improved, but the handleability and resistance to deformation deteriorate
Solution Approach 1:
Dividing the large volume into multiple small granular bodies improves handleability because each small granular body is easy to manipulate and position. The granular nature allows for flexible packing and adjustment during implantation, while the collective arrangement within the bag-shaped body provides overall shape stability.
4Volume of moving object
If conventional adipose tissue transplantation is performed, then the depression area is filled, but the transplanted tissue is quickly absorbed and the depression recurs
Solution Approach 1:
The granular bodies are made of porous bioabsorbable material with controlled pore structures. This porosity allows for cell infiltration and tissue ingrowth while the material provides structural support during the regeneration process. The gradual degradation of the porous material matches the tissue regeneration rate, preventing collapse and ensuring long-term retention of the regenerated tissue volume.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The substrate enables high handleability and regeneration of a large volume of adipose tissue in a normal shape, reducing the need for large incisions and minimizing deformation, while ensuring the substrate's bioabsorbability and safety.
Implementation Method 1
being made of bioabsorbable materials, it is gradually absorbed into the body as the breast regeneration proceeds and eventually disappears
Data Source
AI summary
The present invention aims to provide an adipose tissue regeneration substrate that has high handleability and that enables regeneration of a large volume of adipose tissue in a normal shape. Provided is an adipose tissue regeneration substrate including: a plurality of granular bodies made of a bioabsorbable material, each granular body having an inner space and having on a surface a plurality of openings leading to the inner space; and a bag-shaped body made of a bioabsorbable material, the bag-shaped body having an opening and wrapping the granular bodies.