Bioabsorbable Polyurethanes with Controllable Degradation
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Solution Overview
Problem
Biodegradable polymers used in biomedical applications face issues such as slow degradation rates and potential toxicity, limiting their effectiveness in drug delivery and tissue engineering.
Innovation Solution
Development of novel bioabsorbable and biodegradable polyurethanes, polyamides, and polyesters with controllable degradation profiles, incorporating aromatic amine-containing monomeric units and diisocyanates, which are prepared using specific methods to create polymers suitable for drug delivery, tissue engineering, and medical devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional biodegradable polymers are used, then they provide basic biodegradability, but they exhibit slow degradation rates and potential toxicity
Solution Approach 1:
The patent modifies the chemical structure of biodegradable polymers by incorporating specific monomeric units (formula I) with adjustable parameters (n, R groups, functional groups) to control degradation rate and eliminate toxicity. By changing the molecular structure parameters, the polymer achieves optimal balance between degradation speed and biocompatibility.
Solution Approach 2:
The invention creates composite polymer structures combining different monomeric units (formula I) with varying functional groups and side chains. This composite approach allows synergistic effects where the overall polymer structure achieves improved degradation properties and reduced toxicity that individual components cannot provide alone.
2Duration of action of moving object
If absorbable polymers are designed for biomedical applications, then they need controlled degradation profiles, but this requires complex molecular structures
Solution Approach 1:
The patent divides the polymer into repeating monomeric units (formula I) with distinct functional segments. Each unit contains specific functional groups and side chains that can be independently controlled, allowing systematic adjustment of degradation properties without overwhelming complexity. The segmentation enables modular design of degradation profiles.
Solution Approach 2:
By systematically varying parameters within the monomeric unit structure (n values, R group types, functional group positions), the patent achieves continuous control over degradation profiles. This parameter-based approach provides a manageable framework for tuning polymer behavior without requiring completely new molecular architectures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting polymers exhibit controlled absorption rates, enhanced biocompatibility, and improved mechanical properties, making them suitable for various biomedical applications, including drug delivery and tissue engineering, while minimizing toxicity.
Implementation Method 1
The polymers of the present invention are bioabsorbable and biodegradable
Data Source
AI summary
Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials.