Bioabsorbable Stent Prohealing Layer for Endothelialization
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional stents face challenges such as new intimal growth, inflammation, and inadequate vascular healing due to their material degradation, which can lead to adverse vascular responses and thrombi formation, especially in bioabsorbable stents.
Innovation Solution
A bioabsorbable stent with a prohealing layer to promote endothelialization and a drug-polymer layer for treating inflammation and neointimal proliferation, fabricated using laser-cutting of a bioabsorbable polymer tube with a prohealing coating and therapeutic agents like endothelial cell binding agents and anti-proliferative drugs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If a bioabsorbable stent is used, then the stent can be completely eroded after clinical need ends, but the stent may trigger adverse vascular responses and thrombi formation during degradation
Solution Approach 1:
The stent surface is pre-coated with a prohealing layer containing endothelial cell binding agents and growth factors before implantation. This preliminary preparation promotes rapid endothelialization immediately after deployment, creating a protective barrier before the bioabsorbable material begins to degrade, thereby preventing thrombi formation and adverse vascular responses during the degradation period
Solution Approach 2:
A prohealing coating layer acts as an intermediary between the bioabsorbable stent material and the vascular tissue. This intermediate layer contains endothelial cell binding agents and growth factors that mediate the interaction, promoting beneficial endothelialization while isolating the degrading stent material from direct contact with blood, thus preventing harmful thrombotic responses
2Reliability
If the stent promotes rapid endothelialization, then vascular healing is improved, but the complexity of the stent structure increases due to multiple coating layers
Solution Approach 1:
Multiple functional components are merged into a single integrated prohealing coating layer. The coating combines endothelial cell binding agents, growth factors, and anti-proliferative drugs within one unified structure that can be applied in a single coating process, thereby achieving rapid endothelialization and vascular healing without significantly increasing manufacturing complexity
3Object-affected harmful factors
If anti-proliferative drugs are incorporated into the stent, then neointimal proliferation is reduced, but the manufacturing process becomes more complex
Solution Approach 1:
Anti-proliferative drugs are merged into the prohealing coating layer that is already applied to the stent surface. This integration allows the drugs to be delivered through the same coating process used for applying endothelial cell binding agents and growth factors, thereby reducing neointimal proliferation without adding separate manufacturing steps or significantly increasing fabrication complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stent effectively promotes vascular healing, reduces inflammation, and prevents thrombi formation by enhancing endothelialization and treating neointimal proliferation, ensuring the stent's mechanical properties are maintained during its degradation period.
Implementation Method 1
The prohealing coating layer includes endothelial cell binding agents that promote endothelialization upon exposure to bodily fluids
Implementation Method 2
fabricated using laser-cutting of a bioabsorbable polymer tube
Implementation Method 3
bioabsorbable polymer tube with a prohealing coating and therapeutic agents
Data Source
AI summary
Stents and methods of fabricating stents with prohealing layers and drug-polymer layers are disclosed.