Bioactive Bone Grafts Using Lysing Agents for Fusion
Solution Overview
Problem
Current bone grafts and spinal implants lack effective bioactive agents to stimulate tissue growth and fusion, particularly in degenerative conditions, leading to suboptimal healing and stability in skeletal structures.
Innovation Solution
Development of osteoinductive implants using cellular bone tissue with lysing agents to release growth factors and nutrients, combined with biocompatible materials like chitosan and minerals, to enhance bone growth and fusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional bone grafts and spinal implants are used, then structural support is provided, but tissue growth stimulation and fusion effectiveness are insufficient
Solution Approach 1:
The patent applies parameter changes by incorporating lysing agents that alter the chemical environment to release growth factors from cellular bone tissue. This transforms the implant from a passive structural support to an active bioactive system that stimulates tissue growth through controlled chemical parameter changes (lysing conditions, growth factor release).
Solution Approach 2:
The patent uses composite materials by combining cellular bone tissue with lysing agents and biocompatible materials like chitosan and minerals. This creates a multi-functional composite implant that provides both structural support and bioactive growth stimulation, resolving the contradiction between structural integrity and biological activity.
2Reliability
If cellular bone tissue with lysing agents is used to release growth factors, then bone growth stimulation is enhanced, but implant complexity increases
Solution Approach 1:
The patent applies preliminary action by pre-loading the implant with cellular bone tissue containing growth factors before implantation. The lysing agents are incorporated in advance to release these growth factors in situ, eliminating the need for separate growth factor application steps and simplifying the overall treatment protocol despite the enhanced bioactivity.
3Reliability
If biocompatible materials like chitosan and minerals are combined with bone grafts, then tissue regeneration is enhanced, but manufacturing complexity increases
Solution Approach 1:
The patent merges multiple functional components (cellular bone tissue, lysing agents, chitosan, minerals) into a single integrated implant structure. This combining approach enhances tissue regeneration capabilities while consolidating multiple functions into one manufacturable unit, reducing the complexity of coordinating separate treatments or applications.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of osteoinductive implants with bioactive agents and biocompatible materials significantly promotes bone growth, fusion, and tissue regeneration, addressing the limitations of existing bone grafts and spinal implants.
Implementation Method 1
cellular bone tissue with lysing agents to release growth factors and nutrients
Implementation Method 2
biocompatible materials like chitosan and minerals, to enhance bone growth and fusion
Data Source
AI summary
Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.