Bioactive Surface Coating on Endoprosthesis Balloon Catheter
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Solution Overview
Problem
Conventional stents and balloon catheters often cause vascular wall thickening and lumen narrowing due to cell proliferation, leading to irregular drug distribution and potential lump formation on their surfaces during drug delivery.
Innovation Solution
A method involving wetting the surface of endoprostheses or balloon catheters with an active substance solution, followed by removal of excess substance and solvent through centrifugation or knocking off, to achieve a uniform distribution and prevent lump formation, using solvents like dimethyl sulfoxide and structuring the surface for enhanced drug delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If an active ingredient dissolved in a solvent is applied to the surface of the endoprosthesis or balloon catheter, then drug delivery is enabled, but irregular distribution of the solvent and active substance occurs leading to lump formation
Solution Approach 1:
The surface is pre-treated by enlarging it through mechanical, thermal, or chemical structuring before applying the active substance solution. This preliminary surface modification creates a larger surface area with micro-structures that facilitate more uniform solvent distribution and prevent lump formation during subsequent drug application
Solution Approach 2:
The physical and chemical parameters of the surface are changed by structuring it to create indentations and increased surface area. This parameter change from a smooth surface to a structured surface with 5-50 μm indentations fundamentally alters how the solvent and active substance distribute, enabling uniform coating without lump formation
2Quantity of substance
If the surface is enlarged by structuring or profiling, then surface area increases for better drug loading, but surface complexity increases
Solution Approach 1:
The surface is transformed into a porous or micro-structured material with indentations 5-50 μm deep and wide. This porous structure dramatically increases the surface area available for drug loading while maintaining a relatively simple overall device structure, allowing enhanced drug capacity without proportionally increasing device complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method ensures a uniform bioactive surface coating, preventing clumping and ensuring effective drug delivery, thereby reducing vascular wall thickening and lumen narrowing.
Implementation Method 1
the surface of the endoprosthesis or the surface of the balloon is first wetted with a solution of an active substance
Implementation Method 2
Excess active substance and solvent are advantageously removed from the wetted surface by centrifuging
Implementation Method 3
an active ingredient dissolved in a solvent is applied to the surface of the endoprosthesis or to the surface of the balloon of the balloon catheter, with the solvent then evaporating
Data Source
Figure 1~3
Figure 4~6
Figure 7~9
AI summary
A method for producing a bioactive surface on an endoprosthesis or on the balloon (3) of a balloon catheter (1) is disclosed, wherein the surface of the endoprosthesis or the surface of the balloon (3) is moistened with a solution (6) of an active substance (7), excess active substance (7) and solvent (8) are removed from the moistened surface by moving, for example centrifuging or striking, the endoprosthesis or the balloon (3), and the solvent (8) is separated from the active substance (7).