Bioactive Coating on Porous Polymer Substrates
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Solution Overview
Problem
Existing methods for imparting bioactivity to organic polymer substrates fail to achieve strong adhesion of bone tissues with the substrate, as bone tissues cannot grow inside the pores of porous substrates, limiting the effectiveness of bioactive coatings.
Innovation Solution
A method involving immersion of porous substrates in simulated body fluid with adjusted pH and temperature to deposit calcium phosphate particles within the substrate pores, creating a bioactive coating layer with high adhesion strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If particles comprising calcium phosphate compounds are adhered on the substrate sheet and pressed to embed particles inside the sheet, then bioactivity is imparted to the substrate, but bone tissues cannot grow inside the pores resulting in weak adhesion strength
Solution Approach 1:
The invention utilizes a porous substrate structure with controlled pore size (10 nm to 1 mm) and porosity (10% to 65%) to enable bone tissue infiltration and growth. The porous structure allows calcium phosphate particles to be deposited within the pores, creating a composite material where bone tissues can grow inside the pores, thereby achieving both bioactivity and strong adhesion strength through interlocking effect.
Solution Approach 2:
The invention creates a composite structure combining organic polymer substrate with calcium phosphate compounds deposited within the pores. This composite material integrates the mechanical properties of the polymer substrate with the bioactive properties of calcium phosphate, enabling both structural integrity and biological functionality with strong tissue adhesion.
2Reliability
If a porous substrate is used to allow bone tissue growth, then bioactivity is achieved, but the adhesion strength is insufficient because bone tissues cannot grow inside the pores
Solution Approach 1:
The invention optimizes specific parameters including pore size (10 nm to 1 mm), porosity (10% to 65%), and calcium phosphate particle deposition conditions to enable bone tissue growth within the pores. By controlling these parameters, the substrate achieves both the bioactivity required for tissue growth and the structural conditions necessary for strong adhesion strength through interlocking.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively forms and grows a calcium phosphate coating layer on the surface of porous substrates with high adhesion strength, enhancing bioactivity and tissue integration.
Implementation Method 1
a step of immersing a porous substrate in a solution containing at least calcium ions and hydrogenphosphate ions, thereby distributing the solution to the inside of at least a part of the pores of the substrate
Implementation Method 2
a step of depositing fine particles containing a calcium phosphate compound as the major component inside the pores into which the solution is introduced
Data Source
AI summary
An object of the present invention is to provide a method for producing bioactive composites having imparted thereto bioactivity, to thereby form and grow in vivo or in vitro a coating layer containing a calcium phosphate compound as the major component with a high adhesion strength on the surface of various types of porous substrates such as a porous shaped body comprising an organic polymer. The means for solving the problem is characterized by comprising at least (1) a step of immersing a porous substrate in a solution containing at least calcium ions and hydrogenphosphate ions, thereby distributing the solution to the inside of at least a part of the pores of the substrate, and (2) a step of depositing fine particles containing a calcium phosphate compound as the major component inside the pores into which the solution is introduced.