Bioactive Glass Composition for Controlled Calcium Compound Formation
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Solution Overview
Problem
Current bioactive glasses used for tissue repair and regeneration primarily form hydroxyapatite, which may not be optimal for all applications, as they have slow resorption rates and limited effectiveness in promoting rapid bone growth, whereas other calcium-containing compounds like calcite could facilitate faster bone repair and regeneration.
Innovation Solution
Development of biocompatible glass compositions that include director elements such as Cu, Sr, Zn, and Fe to control the formation of calcium-containing compounds other than hydroxyapatite, specifically promoting the formation of calcite or other calcium compounds that are more osteogenic and resorbable, thereby enhancing tissue repair and regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional bioactive glasses are used to form hydroxyapatite, then bone bonding is achieved, but the resorption rate is slow and bone growth promotion is limited
Solution Approach 1:
The patent modifies the chemical composition parameters of bioactive glass by incorporating specific elements (strontium, zinc, copper, iron) to alter the reaction pathway and control the formation kinetics of calcium phosphate compounds, enabling faster resorption and bone regeneration
Solution Approach 2:
The invention creates composite glass compositions combining multiple metal oxides (SiO2, CaO, P2O5, SrO, ZnO, CuO, Fe2O3, B2O3) in specific ratios to achieve synergistic effects that accelerate bone repair while controlling resorption rate
2Adaptability or versatility
If hydroxyapatite is formed as the primary calcium compound, then chemical bonding to bone is achieved, but other potentially more osteogenic calcium compounds are not formed
Solution Approach 1:
The patent creates spatial and temporal control over calcium compound formation, where different calcium compounds (hydroxyapatite, octacalcium phosphate, dicalcium phosphate) form at different stages and locations during the healing process, optimizing both initial bonding and subsequent regeneration
Solution Approach 2:
The invention enables dynamic control of the calcium phosphate formation process through compositional design, allowing the material to transition between different reaction stages and compound formations as the healing progresses
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The glass compositions effectively form calcite or other calcium compounds in vivo, leading to faster bone repair, reduced resorption times, and improved tissue regeneration by altering the normal calcium compound formation hierarchy, thus overcoming the limitations of traditional hydroxyapatite-forming bioactive glasses.
Implementation Method 1
calcium carbonate or other calcium compounds other than hydroxyapatite form upon bioreaction of the composition with bodily fluids
Data Source
Figure 1A~1C
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AI summary
A biocompatible composition for tissue repair or regeneration in mammals comprising one or more glass former compounds selected from the group consisting of B2O3, P2O5, and SiO2 and director elements selected from the group consisting of Cu, Sr, Zn, Fe, Mn, Cr, V, Nb, Mo, W, Ba, Co, S, Al, Ti, Y, Mg, Si and/or Ni to promote in vivo calcium compound formation of calcium carbonate or other calcium compounds other than hydroxyapatite. Upon direct application of the biocompatible composition to a mammalian host, calcium carbonate or other calcium compounds other than hydroxyapatite form upon bioreaction of the composition with bodily fluids.