Bioactive Stent with Magnetic Coating for Aneurysm Repair

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Solution Overview

Problem

Conventional treatments for wide-necked intracranial aneurysms, such as endovascular coiling, face challenges including thrombosis risk and recurrence due to irregular coil interfaces and failure to address the diseased parent artery segment, necessitating a solution that reduces blood inflow while minimizing thrombogenic occlusion and promoting vessel healing.

Innovation Solution

A minimally invasive endovascular stent with a bioactive coating comprising a magnetic material, ion-beam nanostructured biocompatible layer, and PCSM (porcine coronary smooth muscle) is deployed to attract magnetized cells for targeted healing and tissue growth, using a catheter-based delivery system to reduce blood flow and promote aneurysm occlusion and vessel repair.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If endovascular coiling is used to treat wide-necked aneurysms, then the aneurysm can be occluded, but the risk of thrombosis and stroke increases due to irregular coil interfaces with the parent artery

Engineering Contradiction:

Improveaneurysm occlusion effectivenessVSAvoidthrombosis risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The stent features variable porosity with a low porosity patch at the aneurysm neck region and higher porosity in the body. This local quality differentiation allows the neck region to effectively occlude the aneurysm while maintaining adequate blood flow in the parent artery, reducing thrombosis risk at the critical interface zone

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The stent is constructed as a porous mesh structure with controlled porosity distribution. The porous design allows blood flow through the stent body while the low porosity patch at the neck provides effective sealing, balancing occlusion effectiveness with thrombosis prevention

Inventive Principle:

Principle #31Porous materials

2Ease of operation

If conventional stents are used to maintain coil patency, then the parent artery remains open, but the durability of the affected vessel is impaired and recurrence risk remains high

Engineering Contradiction:

Improveartery patency maintenanceVSAvoidvessel durability

Core Design Contradiction:

Ease of operationVSDuration of action of stationary object

Solution Approach 1:

The stent incorporates a low porosity patch that changes the flow parameters at the aneurysm neck region. This creates controlled flow stagnation and recirculation zones that promote thrombosis within the aneurysm sac while maintaining adequate flow in the parent artery, addressing both patency and durability concerns

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The stent is functionally segmented into a low porosity patch for aneurysm occlusion and a higher porosity body for maintaining parent artery patency. This segmentation allows each region to perform its specific function optimally, improving overall treatment durability

Inventive Principle:

Principle #1Segmentation

3Reliability

If surgical clipping is performed to bypass the aneurysm, then the aneurysm is effectively isolated, but the procedure is highly invasive with longer recovery time

Engineering Contradiction:

Improveaneurysm isolation effectivenessVSAvoidprocedure invasiveness

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The invention replaces the mechanical surgical clipping approach with an endovascular stent-based solution. The stent uses controlled porosity and flow dynamics rather than physical clamping to achieve aneurysm isolation, eliminating the need for open craniotomy and providing a minimally invasive alternative with comparable reliability

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The stent effectively reduces blood flow to the aneurysm, minimizes thrombosis risk, and promotes healing by attracting magnetized cells to the aneurysmal neck, enhancing durability and reducing recurrence risks in a minimally invasive procedure.

Implementation Method 1

The coating includes a magnetic material deposited on portion of an outer surface of the stent... to attract magnetized cells for targeted healing and tissue growth

Methodology Applied

Scientific EffectMagnetic attraction: Magnetism

Implementation Method 2

an ion-beam nanostructured biocompatible layer

Methodology Applied

Scientific EffectIon beam processing: Ion Beam

Data Source

PatentUS9839724B2System and stent for repairing endovascular defects and methods of use

Publication Date: 2017.12.12 THE HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC

AI summary

Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and/or repair damaged vessels.