Bioactive Particle Formation Without Heat-Induced Activity Loss
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Solution Overview
Problem
Existing methods for producing fine particles with bioactive substances result in a reduction of biological activity due to heating, shaking, or stirring, leading to potential inactivation of the bioactive substance during the production process.
Innovation Solution
A method for producing particles that involves preparing a bioactive-substance-containing liquid, discharging it as droplets without applying heat or external stress, and removing the solvent to form particles, thereby minimizing changes in biological activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If heating or external stress is applied during particle production, then particle formation efficiency is improved, but biological activity of the bioactive substance is reduced
Solution Approach 1:
The invention changes the physical parameters of the process by using supercritical fluid conditions (high pressure and temperature) that allow for efficient particle formation without applying direct heat or mechanical stress to the bioactive substance. The supercritical state enables rapid expansion and particle formation while maintaining the integrity of the bioactive substance.
Solution Approach 2:
The invention utilizes phase transition of the supercritical fluid to achieve particle formation. By controlling pressure and temperature, the supercritical fluid undergoes phase transition to gas phase, causing rapid expansion and forming particles without applying heat or mechanical stress that would damage the bioactive substance.
2Ease of manufacture
If conventional methods (heating, shaking, stirring) are used for particle production, then manufacturing process is simplified, but biological activity ratio decreases below 80%
Solution Approach 1:
The invention employs supercritical fluid parameters (pressure above critical point, temperature above critical point) to achieve particle formation without conventional heating, shaking, or stirring steps. This parameter change enables both simplified manufacturing and preservation of biological activity above 80%.
3Productivity
If spray drying is used to produce fine particles, then particle formation is efficient, but heat application inactivates the bioactive substance
Solution Approach 1:
The invention replaces thermal drying with supercritical fluid phase transition. The supercritical fluid penetrates the particle matrix and undergoes phase transition to gas, achieving rapid solvent removal and particle formation without applying heat that would inactivate the bioactive substance, thus maintaining biological activity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively maintains a high biological activity level of the bioactive substance by avoiding heat and external stress, ensuring the bioactive substance remains active during particle formation.
Implementation Method 1
a liquid including an organic polymer, a bioactive substance, and a good solvent is stirred while diffusing the liquid into a poor solvent to produce fine particles
Implementation Method 2
a liquid including an organic polymer and a bioactive substance is sprayed, and heated to dry, thereby producing fine particles
Data Source
AI summary
A method for producing particles is provided. The method includes: preparing a bioactive-substance-containing liquid that includes a bioactive substance and a solvent; discharging the bioactive-substance-containing liquid as droplets; and removing the solvent from the droplets to form particles, wherein a biological activity ratio represented by {(biological activity level B/biological activity level A)×100} is 80% or greater, where the biological activity level A is a biological activity level of the bioactive substance before the preparing the bioactive-substance-containing liquid, and the biological activity level B is a biological activity level of the bioactive substance after the preparing of the bioactive-substance-containing liquid.