Vaso-occlusion Device with Bioactive Polymer Coating
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Solution Overview
Problem
Standard platinum embolization coils are limited in promoting thrombogenicity and stability, leading to potential aneurysm rupture and re-canalization, especially in wider neck aneurysms, due to their biologically inert nature and susceptibility to clot lysis, and may migrate, causing occlusion of the parent vessel.
Innovation Solution
A vaso-occlusion device with a polymeric material having a plurality of holes filled with bioactive agents that promote thrombogenicity and thrombus formation, including thrombogenic, fibrogenic, and angiogenic agents, and resorbable agents to secure the device in the vessel, combined with space-filling structural elements like coils or occlusion bags to enhance occlusion and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If standard platinum embolization coils are used, then the device structure is simple and manufacturing is easy, but the ability to promote thrombogenicity is insufficient and clot stability is poor
Solution Approach 1:
The patent applies composite materials by combining platinum coils with a polymer coating layer containing embedded bioactive agents. This composite structure integrates the mechanical properties of platinum with the thrombogenic properties of the polymer-bioactive agent composite, resolving the contradiction between structural simplicity and enhanced clot stability.
Solution Approach 2:
The patent uses porous polymer material as the coating layer, which allows blood components to penetrate and interact with the embedded bioactive agents. The porous structure enables controlled release of thrombogenic agents while maintaining device integrity, thereby improving clot stability without excessive complexity.
2Reliability
If standard platinum coils are used, then the device is easy to operate and deliver, but migration occurs and parent vessel occlusion risk increases
Solution Approach 1:
The patent modifies the surface parameters of the coil by adding a polymer coating with embedded bioactive agents. This changes the surface properties to enhance thrombogenicity and clot formation, which anchors the device more securely and prevents migration, thereby improving device stability while maintaining deliverability through the same catheter systems.
3Reliability
If standard platinum coils are used, then manufacturing cost is low, but complete packing of aneurysm lumen is not achieved and re-canalization occurs
Solution Approach 1:
The patent applies preliminary action by pre-embedding thrombogenic bioactive agents within the polymer coating before the coil is deployed. This preliminary preparation ensures that upon deployment, the agents are immediately available to promote clot formation and stabilize the occlusion, preventing re-canalization without requiring complex post-deployment procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively promotes clotting, aneurysm retraction, and scarring, providing improved stability and reducing the risk of rupture by enhancing thrombogenicity and securing the occlusion, thus overcoming the limitations of standard embolization coils.
Implementation Method 1
a porous, polymeric material supporting release of bioactive agents
Implementation Method 2
the bioactive agent promotes thrombogenicity, inhibiting thrombolytic activity
Data Source
Figure 1A~1B
Figure 2
AI summary
Compositions and methods for occluding a vessel in a subject are provided in which a vaso-occlusion device includes an occluding element having a polymeric material containing a plurality of holes at least partially filled with one or more bioactive agents, the vaso-occlusion device configured to occlude a vessel in the subject.