Bioactive Material Coated Stent Surface Energy Matching
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Solution Overview
Problem
Existing medical devices coated with bioactive materials face challenges in achieving optimal adhesion and controlled release of drugs due to adverse side effects from polymer carriers and inadequate surface energy matching between the device and the bioactive material.
Innovation Solution
The medical device features a contact surface with a defined total surface energy density, matching the polar and non-polar components of the bioactive material, achieved through techniques like selective etching, polishing, passivation, and ion beam penetration, allowing for improved adhesion and controlled release of the bioactive material.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If polymer carriers are used to adhere drugs to stents for delivery, then the drugs can be delivered into the patient, but adverse side effects occur which are undesirable for the patient
Solution Approach 1:
The invention extracts and eliminates the polymer carrier component from the drug delivery system. Instead of using polymer carriers to adhere and deliver drugs, the patent directly coats the drug onto the stent surface through surface energy matching, thereby removing the source of adverse side effects while maintaining drug delivery functionality
Solution Approach 2:
The invention introduces surface energy density matching as an intermediary mechanism between the stent and the drug. By matching the surface energy densities, the patent achieves effective drug adhesion and controlled release without requiring polymer carriers, thus eliminating harmful side effects
2Strength
If the surface energy densities of the contact surface and bioactive material are matched, then adhesion of the bioactive material is improved, but additional surface treatment steps are required
Solution Approach 1:
The invention changes the surface energy density parameter of the contact surface to match that of the bioactive material. This parameter change is achieved through controlled surface treatments that adjust the surface chemistry, enabling direct drug coating without complex multi-layer polymer systems
3Strength
If roughened or textured surface is provided on stent, then adhesion of bioactive material is increased, but manufacturing complexity increases
Solution Approach 1:
Instead of changing the physical topology of the surface (roughening), the invention changes the surface energy density parameter through chemical or physical surface treatments. This approach achieves enhanced adhesion while maintaining manufacturing simplicity, as the treatments can be applied to smooth surfaces without complex forming operations
4Reliability
If porous surface with composite material is used, then bioactive agent delivery is enabled, but material complexity and manufacturing difficulty increase
Solution Approach 1:
The invention extracts and removes the complex porous composite material structure from the stent design. By matching surface energy densities, the patent enables direct drug coating on simpler surfaces, achieving reliable bioactive agent delivery without the need for porous structures or multi-material composites
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the bonding and elution of bioactive materials from the device, optimizing their delivery and reducing the need for additional polymer layers, while ensuring effective drug release and minimizing adverse reactions.
Implementation Method 1
achieved through techniques like selective etching, polishing, passivation, and ion beam penetration
Implementation Method 2
achieved through techniques like selective etching, polishing, passivation, and ion beam penetration
Implementation Method 3
achieved through techniques like selective etching, polishing, passivation, and ion beam penetration
Implementation Method 4
achieved through techniques like selective etching, polishing, passivation, and ion beam penetration
Implementation Method 5
The polar components of the surface energies are substantially matched and the dispersive (non-polar) components of the surface energies are substantially matched
Implementation Method 6
enhances the bonding and elution of bioactive materials from the device
Data Source
Figure 1~2
Figure 3
AI summary
An implantable medical device includes a bioactive material coated on a contact surface. The contact surface and bioactive material each has a defined surface energy density comprising a polar component and a non-polar component. The polar components of the surface energies are substantially matched and the non-polar components of the surface energies are substantially matched so as to allow optimised bonding and elution of the material when in situ within a patient. A method for manufacturing the device is also provided.