Functionalized Biocatalyst Composition for Lung Tissue Targeting
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Solution Overview
Problem
Existing biocatalytical compositions, as described in WO2015/014888, are not suitable for therapeutic applications due to their lack of biocompatibility and bioavailability, particularly for treating lung cancer.
Innovation Solution
A composition comprising a solid carrier with a particle size between 15 nm and 40 nm, an enzyme or its fragment immobilized on the carrier, a protective layer embedding the enzyme, and a functional constituent on the protective layer, designed to enhance therapeutic efficacy by targeting lung tissue.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If biocatalytical compositions are designed with larger particle sizes for stable enzyme immobilization, then enzyme stability is improved, but tissue distribution and bioavailability are worsened
Solution Approach 1:
The patent applies parameter changes by reducing the particle size of the solid carrier to a specific range (15-40 nm) to optimize both enzyme stability and tissue distribution. This size parameter enables the composition to accumulate in lung tissue while maintaining enzyme stability through the protective layer structure.
Solution Approach 2:
The patent implements nesting by embedding the enzyme within a protective layer that is itself immobilized on the solid carrier surface. This nested structure protects the enzyme while allowing the small particle size to achieve desired tissue distribution.
2Ease of manufacture
If biocatalytical compositions use conventional carrier sizes for ease of manufacture, then manufacturing simplicity is improved, but therapeutic efficacy is worsened
Solution Approach 1:
The patent changes the particle size parameter to 15-40 nm, which balances manufacturing feasibility with therapeutic efficacy. This specific size range allows for practical synthesis while achieving the desired lung tissue accumulation and cancer treatment effectiveness.
3Stability of the object's composition
If protective layers are made thicker for better enzyme protection, then enzyme protection is improved, but bioavailability is worsened
Solution Approach 1:
The patent applies local quality by creating a protective layer with specific local properties optimized for both enzyme protection and bioavailability. The protective layer is engineered with appropriate thickness and composition to protect the enzyme while allowing sufficient interaction with the biological environment for therapeutic effect.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves unexpected tissue distribution in the lung, making it promising for therapeutic use in treating lung cancer.
Implementation Method 1
an enzyme or a fragment thereof immobilized on the surface of the solid carrier
Implementation Method 2
compositions as provided by the present invention if applied therapeutically have an unexpected tissue distribution resulting in a major accumulation in the lung
Data Source
AI summary
The present invention relates to a composition comprising a solid carrier, an enzyme or a fragment thereof immobilized on the surface of the solid carrier, a protective layer to protect the enzyme or the fragment thereof by embedding the enzyme or the fragment thereof, and a functional constituent immobilized on the surface of the protective layer. The present invention also relates to a method for the prevention, delay of progression or treatment of lung cancer in a subject using said composition and methods of producing said composition.