Biochemical Detection Device with Dissolvable Layer for Incubation Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional portable point-of-care detection devices require significant user intervention, leading to potential operation errors and reduced reliability, particularly in controlling reaction incubation time for accurate biochemical detection.
Innovation Solution
A biochemical detection device with a controlled reaction incubation time is developed, featuring a substrate with a dissolvable material layer and an absorbing material layer, where the reaction space is defined by openings of different diameters, allowing passive control of reaction time through the dissolution rate of the dissolvable material layer, minimizing user intervention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a conventional portable point-of-care detection device uses an immunochromatographic rapid test strip based on a porous paper structure, then the user can perform a very simple visual check with minimal intervention, but the device cannot achieve accurate quantitative analysis with high detection sensitivity
Solution Approach 1:
The device is segmented into distinct functional layers: a dissolvable material layer that controls reaction time, an absorbing material layer that manages fluid flow, and a detection layer with probes. This segmentation allows each layer to specialize in one function, enabling both ease of operation and measurement precision simultaneously
Solution Approach 2:
The dissolvable material layer acts as an intermediary between the sample injection and the detection region. It passively controls the reaction incubation time by dissolving at a predetermined rate, eliminating the need for user intervention while ensuring accurate quantitative analysis through controlled reaction conditions
2Measurement precision
If a microfluidic element-based device is used to perform quantitative analysis with precise treatment of small amounts of reagent and sample, then detection sensitivity is improved, but user intervention is required for each step which may cause operation errors
Solution Approach 1:
The device performs self-service through the dissolvable material layer that automatically controls the reaction incubation time. The layer dissolves passively at a predetermined rate, transferring the liquid sample to the absorbing material layer without user intervention, thereby eliminating operation errors while maintaining quantitative analysis accuracy
Solution Approach 2:
The dissolvable material layer's dissolution rate is carefully controlled to match the required reaction incubation time. By changing the material parameters (dissolution rate, thickness), the device automatically adjusts the reaction time parameter, enabling accurate quantitative analysis without user intervention
3Reliability
If a fully automated detection reaction device is developed to minimize user intervention, then operation reliability is improved, but device complexity increases
Solution Approach 1:
The complex automation mechanism is extracted and replaced by a simple dissolvable material layer. Instead of using complex mechanical or electronic automation systems, the invention extracts the time-control function and implements it through a passive chemical dissolution process, reducing device complexity while maintaining high reliability
Solution Approach 2:
The mechanical automation system for controlling reaction time is replaced by a chemical dissolution process. The dissolvable material layer uses chemical dissolution rather than mechanical actuators or electronic controllers to manage the reaction incubation time, significantly simplifying the device structure while improving reliability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves constant and accurate detection results with reduced user interaction by passively controlling reaction time and enabling efficient sample transfer and washing without external forces, enhancing the reliability of point-of-care detection.
Implementation Method 1
the dissolvable material layer is dissolved by the liquid sample
Implementation Method 2
the liquid sample has been transferred to the absorbing material layer
Data Source
AI summary
A biochemical detection device with a controlled reaction incubation time includes a substrate; a probe disposed on the substrate; a dissolvable material layer disposed on the substrate, wherein the dissolvable material layer has a first opening defined therein, wherein the probe is received in the first opening; an absorbing material layer disposed on the dissolvable material layer and having a second opening defined therein, wherein the first opening communicates with the second opening and is smaller than the second opening; and a non-dissolvable material layer disposed on an inner face of the second opening of the absorbing material layer and on an exposed top face of the dissolvable material layer.