Biochip Detector Light Source Self-Compensation
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Solution Overview
Problem
Biochip detecting devices, such as flow cytometers, face challenges in accurately detecting light source attenuation and require complex procedures for light source replacement, which can affect detection results and user convenience.
Innovation Solution
A biochip detecting device equipped with an optical attenuator, filter, sensor, and control module that allows for self-detection and self-compensation of light source intensity by attenuating incident light and adjusting the driving voltage of the light source, eliminating the need for external detectors and minimizing device disassembly.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a flow cytometer uses multiple light sources and photo detectors to detect physical and chemical properties of cells, then the detection capability is improved, but the device complexity increases
Solution Approach 1:
The patent combines multiple light sources (laser and LED) into a single detection system, allowing both to illuminate the flow cell simultaneously. The photodetector array captures signals from both sources, merging their detection capabilities into one integrated system rather than requiring separate detection pathways.
Solution Approach 2:
The photodetector array serves multiple functions: it detects scattered light from the laser, captures fluorescence from the LED-excited fluorophores, and can identify both cell presence and specific markers. This multi-functional design eliminates the need for separate detection systems for different measurement types.
2Measurement precision
If the light source property attenuates in a biochip detecting device, then the detection accuracy deteriorates, but replacing the light source requires device disassembly and specific detectors
Solution Approach 1:
The system performs preliminary detection of light source intensity using the photodetector array before actual cell detection. By continuously monitoring the intensity of scattered light and fluorescence signals, the system can identify when light source attenuation occurs and trigger alerts or automatic compensation before detection accuracy is compromised.
Solution Approach 2:
The photodetector array provides continuous feedback on light source performance by measuring scattered light intensity and fluorescence signal strength. This feedback mechanism allows the system to monitor light source attenuation in real-time and maintain detection accuracy through compensatory adjustments or maintenance scheduling.
3Measurement precision
If a specific light source element detector is used to detect the light source, then the detection accuracy is improved, but the device complexity and operation difficulty increase
Solution Approach 1:
The photodetector array is designed to perform multiple detection functions simultaneously: it detects scattered light for cell counting, captures fluorescence for marker identification, and monitors light source intensity for maintenance scheduling. This universal detector eliminates the need for separate specialized detectors for each function.
Solution Approach 2:
The system merges the light source detection function with the primary cell detection function by using the same photodetector array to measure both scattered light from cells and the intensity reference signals. This consolidation allows light source monitoring to occur during normal operation without requiring additional detection hardware.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables convenient and accurate detection of light source attenuation and intensity adjustment within the device, improving operational efficiency and user convenience by integrating self-detection and compensation capabilities.
Implementation Method 1
The optical attenuator is removably disposed between the light source and the filter to attenuate an intensity of the incident light
Implementation Method 2
The filter filters light with a wavelength other than the specific wavelength
Implementation Method 3
The sensor detects an intensity of the light with the specific wavelength attenuated by the optical attenuator
Data Source
AI summary
A biochip detecting device for detecting a biochip is provided. The biochip receives an incident light to produce an excitation light. Both the incident light and the excitation light include a specific wavelength. The biochip detecting device includes a light source producing the incident light, an optical attenuator, a filter, a sensor, and a control module electrically connected to the light source and the sensor. Light with the specific wavelength passes through the filter. The optical attenuator disposed between the light source and the filter attenuates an intensity of the incident light, and replaces the biochip. The sensor detects an intensity of the light with the specific wavelength attenuated by the optical attenuator, and generates an intensity signal. The control module adjusts the intensity of the incident light according to whether the intensity signal is complied with a predetermined requirement. A detection method for the light source is provided.