Biochip Probe Pattern Learning for Low-Cost Microbe Identification
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Solution Overview
Problem
Existing methods for identifying microbial contaminants in food and beverages are costly due to the need for unique base sequences for each probe, leading to high costs and inefficiencies in probe production.
Innovation Solution
A biochip system with probes having common base sequences for multiple microbes, utilizing a detection unit to identify microbial contaminants based on the position pattern of hybridized probes, and a learning model to determine the contaminant type, reducing the need for unique probes and lowering costs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If unique base sequences are used for each probe to identify different microbes, then identification accuracy is improved, but probe production cost increases
Solution Approach 1:
The patent applies universality by designing probes with common base sequences that can identify multiple different microbes simultaneously. Instead of creating unique probes for each microbe, a single probe design serves multiple identification purposes, reducing probe production costs while maintaining identification accuracy through pattern recognition of hybridization results
Solution Approach 2:
The patent transitions from one-dimensional identification (unique probe per microbe) to multi-dimensional identification (common probe for multiple microbes). By analyzing the position patterns of hybridized probes across different locations on the biochip, the system achieves microbe-specific identification using shared probe sequences, adding a spatial dimension to the identification process
2Adaptability or versatility
If multiple unique probes are produced for different microbes, then comprehensive microbial detection is improved, but production efficiency decreases
Solution Approach 1:
The patent implements universality by creating probes with common base sequences that can detect multiple different microbes. This single probe design performs the function of what would traditionally require multiple unique probes, thereby comprehensive microbial detection is achieved while production efficiency increases due to reduced probe variety
Solution Approach 2:
The patent merges the functionality of multiple unique probes into a single probe design with common base sequences. By combining detection capabilities for multiple microbes into one probe type, the system reduces production complexity and increases efficiency while maintaining comprehensive detection coverage through spatial pattern analysis
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively identifies microbial contaminants by analyzing the position pattern of hybridized probes, reducing probe costs and enhancing efficiency in microbial identification.
Implementation Method 1
detecting, by the detection unit, a position of the probe hybridized with the nucleic acid of the microbe
Data Source
AI summary
Provided is an apparatus including: a detection unit which detects a position of a probe hybridized with a nucleic acid included in a specimen among a plurality of probes each of which being provided at a unique position within a biochip and at least some probes of which each having a base sequence different from one another; and a learning processing unit which performs a learning processing of a model which outputs a type of an organism having the nucleic acid included in the specimen in response to a pattern of the position of the probe hybridized with the nucleic acid included in the specimen being newly input, by using learning data including the pattern of the position of the probe hybridized with the nucleic acid included in the specimen and detected by the detection unit, and the type of the organism having the nucleic acid included in the specimen.