Bio-chip Segmentation for Selective Biomaterial Analysis
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Solution Overview
Problem
Existing bio-chips require the analysis of entire biomaterials attached, making them inefficient for selective analysis and costly due to the need for large amounts of reagents, which is time-consuming and expensive.
Innovation Solution
A bio-chip design featuring a fixing plate with guide grooves and support plates with pillars, allowing for the separation and analysis of biomaterials from specific regions using magnetic substances and connecting members, enabling individual analysis of biomaterials attached to a single chip.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If the entire bio-chip is used for analysis, then all biomaterials can be tested, but the cost and time increase due to large amounts of reagents required
Solution Approach 1:
The bio-chip is divided into multiple independent analysis regions, each capable of separate analysis. The separation structure allows selective analysis of specific regions containing target biomaterials, reducing reagent consumption while maintaining analysis capability.
Solution Approach 2:
Different regions of the bio-chip are designed with specific functions - some regions contain biomaterials requiring analysis while others serve as control or reference areas. This local differentiation allows targeted analysis of only necessary regions, optimizing reagent usage.
2Loss of substance
If selective analysis of specific regions is implemented, then reagent consumption decreases, but the device complexity increases due to separation structures
Solution Approach 1:
The chip structure is segmented into distinct analysis regions separated by physical barriers or channels. This segmentation enables selective access to specific regions containing target biomaterials, reducing reagent consumption to only the necessary analysis areas.
Solution Approach 2:
The separation structures are integrated within the existing chip architecture, with analysis regions nested within the overall chip structure. This nested design achieves selective analysis capability without adding significant external complexity to the device.
3Loss of time
If the bio-chip allows individual analysis of biomaterials, then analysis time is reduced, but the manufacturing complexity increases
Solution Approach 1:
The chip is manufactured with pre-defined separate analysis regions, each capable of independent analysis. This segmentation allows parallel processing of multiple biomaterials simultaneously, reducing total analysis time while using standard manufacturing techniques.
Solution Approach 2:
The separation structures and analysis regions are designed with universal characteristics that can be replicated across multiple chips using the same manufacturing process, reducing manufacturing complexity despite the enhanced functionality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the selective separation and analysis of biomaterials from specific regions on a single bio-chip, reducing costs and time by allowing individual analysis procedures to be conducted efficiently.
Implementation Method 1
Here, the guide groove may include a magnetic substance provided therein. Here, the support plate may have a magnetic material coated on an upper surface thereof.
Data Source
AI summary
There is provided a bio-chip, including a fixing plate having a plurality of guide grooves formed in one surface thereof, a first substrate having a plurality of support plates inserted into the guide grooves, and a plurality of pillars protruded from one surface of the respective support plates, and having a biomaterial disposed thereon.