Biocompatible Adhesive Antiadhesive Barrier Mesh Implant Fixation
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Solution Overview
Problem
Synthetic mesh implants and their fixation devices often cause foreign body reactions, leading to tissue adhesions, seroma formation, and chronic pain due to mechanical fixation methods like sutures and tacks, which can result in complications such as bowel adhesion and obstruction.
Innovation Solution
A method involving a biocompatible adhesive to attach an antiadhesive barrier to the mesh implant, covering both the mesh and fixation devices, reducing direct contact with tissues and minimizing adhesion formation by creating a smooth, atraumatic interface.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If mechanical fixation devices (sutures, tacks, anchors) are used to attach mesh implant to tissue, then fixation strength and stability are improved, but foreign body reaction and adhesion formation increase
Solution Approach 1:
A biocompatible adhesive is introduced as an intermediary substance between the mesh implant and the tissue. This adhesive mediates the fixation process by providing a bonding interface that reduces direct mechanical penetration into the tissue, thereby decreasing foreign body reaction and adhesion formation while maintaining fixation strength.
Solution Approach 2:
The patent replaces part of the mechanical fixation system (sutures, tacks, anchors) with a chemical bonding system (biocompatible adhesive). This substitution reduces the need for penetrating mechanical devices that cause tissue trauma and subsequent adhesion formation, while still achieving secure fixation.
2Object-generated harmful factors
If antiadhesive barrier is applied to mesh implant, then adhesion formation is reduced, but device complexity increases
Solution Approach 1:
The biocompatible adhesive and antiadhesive barrier are combined into a single integrated application step. The adhesive serves dual functions: bonding the mesh to tissue and providing an antiadhesive surface when applied to the mesh implant, thereby reducing device complexity while maintaining adhesion prevention.
Solution Approach 2:
The biocompatible adhesive is designed to perform multiple functions simultaneously: it acts as both a fixation agent (bonding mesh to tissue) and an antiadhesive barrier (preventing adhesion formation). This multi-functionality reduces the need for separate components, thereby simplifying the overall device structure.
3Reliability
If biocompatible adhesive is used to attach antiadhesive barrier to mesh implant, then biocompatibility and adhesion prevention are improved, but manufacturing complexity increases
Solution Approach 1:
The biocompatible adhesive is pre-applied to the mesh implant during manufacturing, and the antiadhesive barrier is then applied over it in a single continuous process. This preliminary action integrates multiple steps into a streamlined manufacturing sequence, reducing overall complexity while ensuring biocompatibility and adhesion prevention.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly reduces postoperative adhesion formation and complications by providing a biocompatible and atraumatic fixation of antiadhesive barriers to mesh implants, decreasing the need for mechanical fixation devices and associated risks, while enhancing mesh integration and reducing seroma incidence.
Implementation Method 1
covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive
Data Source
AI summary
The present invention provides a method of fixating a mesh implant to a tissue of a subject comprising attaching said mesh implant to said tissue, covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive.