Biocompatible Biochips for Cellular Sensing and Therapy

The device is divided into two distinct substrates: a first semiconductor substrate containing sensor devices for detecting physiological parameters, and a second semiconductor substrate containing control circuits and memory. This segmentation allows each substrate to be optimized for its specific function while maintaining overall system integration, enabling cellular-level measurement precision without excessive complexity in a single monolithic structure.

The patent implements a hierarchical nesting structure where the first and second semiconductor substrates are positioned in relationship to each other within a common housing, with sensor devices nested on the first substrate and control circuits nested on the second substrate. This nested arrangement enables compact integration of multiple functional layers, achieving complex cellular-level monitoring capabilities within a manageable device footprint.

The device employs composite material structures including semiconductor substrates coated with biocompatible materials, and housing constructed from biocompatible substances. This composite approach combines the electronic functionality of semiconductors with the biocompatibility of specialized coatings and housing materials, enabling reliable real-time monitoring while minimizing immune rejection and tissue reaction.

The patent introduces biocompatible coatings as intermediary layers between the semiconductor components and the biological environment. These coating layers act as mediators that protect the semiconductor devices from direct contact with bodily fluids and tissues, preventing harmful interactions while allowing the device to function reliably for real-time monitoring of physiological parameters.